Evidence map›Paper›PMID 42039592›Full record

ArticlebioRxiv : the preprint server for biology2026

Loss of enteric BDNF-TrkB signaling and VIPergic dysfunction underlie gastrointestinal dysmotility in a

Srinivas N Puttapaka, Israel A Admasu, Ainsleigh Scott, Gamze Sonmez, Philippa Seika, Mahalakshmi Rajkumar, Xavier Valencia, Alan Consorti, Su Min Hong, Jared Slosberg and 2 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Srinivas N PuttapakaDivision of Gastroenterology, Dept of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
Israel A AdmasuF.M. Kirby Neurobiology Center, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.
Ainsleigh ScottDivision of Gastroenterology, Dept of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
Gamze SonmezDivision of Gastroenterology, Dept of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
Philippa SeikaDivision of Gastroenterology, Dept of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
Mahalakshmi RajkumarDivision of Gastroenterology, Dept of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
Xavier ValenciaF.M. Kirby Neurobiology Center, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.
Alan ConsortiF.M. Kirby Neurobiology Center, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.
Su Min HongDivision of Gastroenterology, Dept of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
Jared SlosbergDept of Genetic Medicine, Johns Hopkins University, Baltimore, MD, USA.
Michela FagioliniF.M. Kirby Neurobiology Center, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.
Subhash KulkarniDivision of Gastroenterology, Dept of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.ORCID 0000-0002-2298-0623

Funding

Identification of enteric Juvenile Protective Factors and their role in stimulating neurogenesis in the adult and ageing Enteric Nervous SystemR01AG066768 · NIA · JOHNS HOPKINS UNIVERSITY · PI GOFF, LOYAL ANDREW, KULKARNI, SUBHASH · 2021 to 2025
$3.3M
Predoctoral Training Program in Human GeneticsT32GM148383 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI Kimberly F Doheny, ANDREW S MCCALLION · 2023 to 2026
$2.4M
Developing a Microphysiological System of a Humanized Gut-Brain-Axis for Ageassociated Transmissible NeuropathologiesR21AG072107 · NIA · JOHNS HOPKINS UNIVERSITY · PI KOPPES, ABIGAIL NELSON, KULKARNI, SUBHASH · 2022 to 2023
$484k
NIA NIH HHS R01 AG066768NIA NIH HHS R21 AG072107NIGMS NIH HHS T32 GM148383
6 · The paper itself

Abstract

Gastrointestinal (GI) dysmotility is a highly prevalent and clinically significant feature of Rett syndrome (RTT), yet its underlying mechanisms remain poorly defined. Here, we investigated these mechanisms of GI dysmotility in a

Identifiers

PMID42039592
PMCPMC13104802

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.