Evidence map›Paper›PMID 42039590›Full record

ArticlebioRxiv : the preprint server for biology2026

Serial vaccination expands and refines human CD4

Yi-Hui Lai, Xi Su, Silina Awad, Asgar Ansari, Juneil Jang, Ali O Saber, Huang-Wen Chen, Hannah Jung, Annesha Sarkar, Elizabeth M Drapeau and 3 more

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Yi-Hui LaiDepartment of Medicine, Division of Rheumatology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Xi SuCorporal Michael J Crescenz VA Medical Center, Philadelphia, PA, 19104, USA.
Silina AwadCorporal Michael J Crescenz VA Medical Center, Philadelphia, PA, 19104, USA.
Asgar AnsariDepartment of Medicine, Division of Rheumatology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Juneil JangDepartment of Medicine, Division of Rheumatology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Ali O SaberDepartment of Medicine, Division of Rheumatology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Huang-Wen ChenDepartment of Medicine, Division of Rheumatology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Hannah JungCorporal Michael J Crescenz VA Medical Center, Philadelphia, PA, 19104, USA.
Annesha SarkarCorporal Michael J Crescenz VA Medical Center, Philadelphia, PA, 19104, USA.
Elizabeth M DrapeauDepartment of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA USA.
Warren B BilkerDepartment of Biostatistics, Epidemiology, and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia PA 19104, USA.
Scott E HensleyDepartment of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA USA.
Laura F SuCorporal Michael J Crescenz VA Medical Center, Philadelphia, PA, 19104, USA.

Funding

The impact of T cell selection on vaccine durabilityR01AI166358 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI SU, LAURA · 2021 to 2025
$3.1M
From Gut to Blood: Dissecting the mechanisms of CD4+ T cell pathology in islet autoimmunity across tissue environments.R01DK140741 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI Ali Naji, Laura Su · 2024 to 2026
$2.4M
CSRD VA I01 CX001460NIAID NIH HHS R01 AI166358NIDDK NIH HHS R01 DK140741
6 · The paper itself

Abstract

CD4

Identifiers

PMID42039590
PMCPMC13104843

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.