Evidence map›Paper›PMID 42039589›Full record

ArticlebioRxiv : the preprint server for biology2026

Arachidonic acid availability controls neutrophil swarm initiation and scaling.

Evelyn D Strickland, Rosheni Kandaswamy, Patrick J Zager, Henry de Belly, Tasha K Phillips, Alex Hopke, Orion D Weiner

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Evelyn D StricklandCardiovascular Research Institute, University of California San Francisco, San Francisco, CA, USA.ORCID 0000-0001-5131-5174
Rosheni KandaswamyCardiovascular Research Institute, University of California San Francisco, San Francisco, CA, USA.ORCID 0009-0009-3407-0692
Patrick J ZagerCardiovascular Research Institute, University of California San Francisco, San Francisco, CA, USA.ORCID 0000-0002-3993-9686
Henry de BellyCardiovascular Research Institute, University of California San Francisco, San Francisco, CA, USA.ORCID 0000-0003-2452-4450
Tasha K PhillipsDepartment of Biomedical Sciences, East Tennessee State University Quillen College of Medicine, PO Box 70577, Johnson City, TN 37614, USA.ORCID 0009-0004-7192-6350
Alex HopkeDepartment of Biomedical Sciences, East Tennessee State University Quillen College of Medicine, PO Box 70577, Johnson City, TN 37614, USA.ORCID 0000-0003-4860-4121
Orion D WeinerCardiovascular Research Institute, University of California San Francisco, San Francisco, CA, USA.ORCID 0000-0002-1778-6543

Funding

Cellular Decision Making Diversity SupplementR35GM118167 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Orion D Weiner · 2016 to 2026
$10.3M
Characterization of Neutrophil Decision making during Swarming to Fungal PathogensK22AI163399 · NIAID · EAST TENNESSEE STATE UNIVERSITY · PI HOPKE, ALEX · 2023 to 2024
$269k
Membrane tension as a long-range integrator of cell physiologyK99GM154115 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI DE BELLY, HENRY · 2024 to 2025
$239k
NIAID NIH HHS K22 AI163399NIGMS NIH HHS K99 GM154115NIGMS NIH HHS R35 GM118167
6 · The paper itself

Abstract

Neutrophils are first responders of the vertebrate immune system. To efficiently converge on sites of injury and infection, neutrophils engage in a collective migration process known as swarming, in which a small number of activated cells generate amplified recruitment of hundreds to thousands of additional neutrophils. How neutrophils initiate, scale, and terminate these swarms is not well understood. Here we define key roles for the mechanosensitive phospholipase cPLA

Indexed as

arachidonic acidbiological self-organizationchemotaxiscollective migrationcPLA2mechanosensingneutrophil swarming

Identifiers

PMID42039589
PMCPMC13105142

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.