Evidence map›Paper›PMID 42039573›Full record

ArticlebioRxiv : the preprint server for biology2026

Dynamic regulation of long non-coding RNAs across asexual and gametocyte development in

Janne Grünebast, Ritwik Singhal, Sophie Olson, Robin Bromley, Sachie Kanatani, Katie Ko, Julie Dunning Hotopp, Photini Sinnis, Manuel Llinás, David Serre

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Janne GrünebastInstitute for Genome Sciences, University of Maryland School of Medicine, Baltimore, MD, USA.ORCID 0009-0005-1329-4241
Ritwik SinghalDepartment of Biochemistry and Molecular Biology and Huck Center for Malaria Research, Pennsylvania State University, University Park, Pennsylvania, USA.ORCID 0000-0003-3626-3489
Sophie OlsonDepartment of Biochemistry and Molecular Biology and Huck Center for Malaria Research, Pennsylvania State University, University Park, Pennsylvania, USA.ORCID 0009-0003-4371-4900
Robin BromleyInstitute for Genome Sciences, University of Maryland School of Medicine, Baltimore, MD, USA.ORCID 0000-0003-2738-2603
Sachie KanataniJohns Hopkins Malaria Institute, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.ORCID 0000-0002-7072-0447
Katie KoInstitute for Genome Sciences, University of Maryland School of Medicine, Baltimore, MD, USA.ORCID 0009-0006-4116-1443
Julie Dunning HotoppInstitute for Genome Sciences, University of Maryland School of Medicine, Baltimore, MD, USA.ORCID 0000-0003-3862-986X
Photini SinnisJohns Hopkins Malaria Institute, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.ORCID 0000-0003-2954-7547
Manuel LlinásDepartment of Biochemistry and Molecular Biology and Huck Center for Malaria Research, Pennsylvania State University, University Park, Pennsylvania, USA.ORCID 0000-0002-6173-5882
David SerreInstitute for Genome Sciences, University of Maryland School of Medicine, Baltimore, MD, USA.ORCID 0000-0002-2446-9095

Funding

Technology CoreU19AI110820 · NIAID · UNIVERSITY OF MARYLAND BALTIMORE · PI RASKO, DAVID A · 2014 to 2023
$36.5M
Multi-Omics Characterization of Plasmodium Vivax HypnozoitesR01AI172827 · NIAID · UNIVERSITY OF MARYLAND BALTIMORE · PI David Serre · 2023 to 2026
$2.8M
The Skin Phase of Malaria Infection (Sharon Patray Diversity Supplement)R01AI132359 · NIAID · JOHNS HOPKINS UNIVERSITY · PI SINNIS, PHOTINI · 2017 to 2021
$2.7M
Characterization of Plasmodium falciparum long non-coding RNAs and their roles in gene regulationR21AI194421 · NIAID · UNIVERSITY OF MARYLAND BALTIMORE · PI LLINAS, MANUEL, SERRE, DAVID · 2025 to 2025
$445k
Image-based quantification of Plasmodium sporozoites in a single oocyst using deep learning-based segmentation and 3D reconstructionR03AI180804 · NIAID · JOHNS HOPKINS UNIVERSITY · PI KANATANI, SACHIE, SINNIS, PHOTINI · 2024 to 2025
$161k
NIAID NIH HHS R01 AI132359NIAID NIH HHS R01 AI172827NIAID NIH HHS R03 AI180804NIAID NIH HHS R21 AI194421NIAID NIH HHS U19 AI110820
6 · The paper itself

Abstract

Long non-coding RNAs (lncRNAs) are critical regulators of gene expression in eukaryotes. Short reads from Illumina sequencing, reverse transcriptase artefacts, and incomplete second-strand degradation in strand-specific cDNA libraries hamper genome-wide identification of lncRNAs, especially in gene-dense genomes such as

Identifiers

PMID42039573
PMCPMC13105063

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.