Evidence map›Paper›PMID 42039543›Full record

ArticlebioRxiv : the preprint server for biology2026

The External Globus Pallidus is a Basal Ganglia Output Hub with Action-Specific Circuits.

Zirong Gu, Zachary R Lewis, Jonathan Tang, Alana Mendelsohn, Ana M Vicente, Laudan Nikoobakht, Sofia Rosenberg, Ananya Chakravarth, Vitor Paixao, Mihir S Tirumalasetti and 21 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

31 authors.

Zirong GuZuckerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA.
Zachary R LewisAllen Institute, Seattle, WA, USA.
Jonathan TangZuckerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA.
Alana MendelsohnZuckerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA.
Ana M VicenteZuckerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA.
Laudan NikoobakhtZuckerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA.
Sofia RosenbergZuckerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA.
Ananya ChakravarthZuckerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA.
Vitor PaixaoChampalimaud Neuroscience Programme, Champalimaud Research, Champalimaud Foundation, Lisbon, Portugal.
Mihir S TirumalasettiThe University of Texas at Dallas, School of Behavioral and Brain Sciences, Department of Neuroscience, Richardson, TX, USA.
Ghada A AbuagalaThe University of Texas at Dallas, School of Behavioral and Brain Sciences, Department of Neuroscience, Richardson, TX, USA.
Amir KhaliliThe University of Texas at Dallas, School of Behavioral and Brain Sciences, Department of Neuroscience, Richardson, TX, USA.
Emma D ThomasAllen Institute, Seattle, WA, USA.
Katherine A FancherAllen Institute, Seattle, WA, USA.
Matt MalloryAllen Institute, Seattle, WA, USA.
Arena ManningAllen Institute, Seattle, WA, USA.
Darren BertagnolliAllen Institute, Seattle, WA, USA.
Jeff GoldyAllen Institute, Seattle, WA, USA.
Christine RimorinAllen Institute, Seattle, WA, USA.
Michael TieuAllen Institute, Seattle, WA, USA.
Trangthanh CardenasAllen Institute, Seattle, WA, USA.
Amy TorkelsonAllen Institute, Seattle, WA, USA.
Anish Bhaswanth ChakkaAllen Institute, Seattle, WA, USA.
Shenqin YaoAllen Institute, Seattle, WA, USA.
Staci A SorensenAllen Institute, Seattle, WA, USA.
Kimberly A SmithAllen Institute, Seattle, WA, USA.
Luke A HammondZuckerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA.
Darcy S PeterkaZuckerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA.
Hongkui ZengAllen Institute, Seattle, WA, USA.
Bosiljka TasicAllen Institute, Seattle, WA, USA.
Rui M CostaZuckerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA.

Funding

Modeling multi-area dynamics during motor controlU19NS104649 · NINDS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI JESSELL, THOMAS M. · 2017 to 2021
$15.3M
Action-Specific Dissecting of Basal Ganglia: from the Classical Model to Diverse Action-Specific SubcircuitsR00NS119788 · NINDS · UNIVERSITY OF TEXAS DALLAS · PI Zirong Gu · 2024 to 2026
$715k
Action-specific dissecting of basal ganglia: from the classical model to diverse action-specific subcircuitsK99NS119788 · NINDS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI GU, ZIRONG · 2021 to 2022
$251k
NINDS NIH HHS K99 NS119788NINDS NIH HHS R00 NS119788NINDS NIH HHS U19 NS104649
6 · The paper itself

Abstract

The external globus pallidus (GPe) is traditionally viewed as a homogeneous relay in the indirect basal ganglia pathway that broadly suppresses movement. Using whole-brain anterograde axon mapping, rabies tracing, single-neuron reconstruction, and single-nucleus RNA sequencing, we reveal that the GPe is a major basal ganglia output nucleus, composed of anatomically and molecularly distinct populations. Besides the neurons with canonical projections, and projections to striatum and cortex, the GPe contains specific neuronal populations that target the thalamus and brainstem directly, including the parafascicular thalamus (GPe

Identifiers

PMID42039543
PMCPMC13104945

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.