Evidence map›Paper›PMID 42039542›Full record

ArticlebioRxiv : the preprint server for biology2026

Dynamic-Structure Redesign of Calmodulin Reveals Mechanistic Constraints on Ryr2 Regulation.

Vladimir Bogdanov, Svetlana Tikunova, Nicolas Fadell, Robyn T Rebbeck, Melanie L Aprahamian, Md Nure Alam Afsar, Aleksei Chekodanov, Daniel J Blackwell, Bjorn C Knollmann, Razvan L Cornea and 5 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Vladimir BogdanovThe Dorothy M. Davis Heart and Lung Research Institute, The Ohio State University Wexner Medical Center, Columbus, Ohio, 43210.ORCID 0000-0001-9287-5303
Svetlana TikunovaThe Dorothy M. Davis Heart and Lung Research Institute, The Ohio State University Wexner Medical Center, Columbus, Ohio, 43210.
Nicolas FadellDepartment of Physiology and Cell Biology, College of Medicine, The Ohio State University, Columbus, Ohio, 43210.
Robyn T RebbeckDepartment of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minnesota, Minneapolis, 55455.
Melanie L AprahamianDepartment of Chemistry and Biochemistry, Ohio State University, Columbus, Ohio 43210, United States.
Md Nure Alam AfsarDepartment of Chemistry, Mississippi State University, Starkville, Mississippi, 39759.
Aleksei ChekodanovIndependent Software Developer, Moscow, Russia, 119049.
Daniel J BlackwellVanderbilt Center for Arrhythmia Research and Therapeutics, Division of Clinical Pharmacology, Vanderbilt University Medical Center, Nashville, Tennessee, 37212.
Bjorn C KnollmannVanderbilt Center for Arrhythmia Research and Therapeutics, Division of Clinical Pharmacology, Vanderbilt University Medical Center, Nashville, Tennessee, 37212.ORCID 0000-0003-4956-9735
Razvan L CorneaDepartment of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minnesota, Minneapolis, 55455.ORCID 0000-0001-5739-0992
Pete M Kekenes-HuskeyDepartment of Cell and Molecular Physiology, Stritch School of Medicine, Loyola University Chicago, Maywood, Illinois, 60153.ORCID 0000-0001-7286-3022
Steffen LindertDepartment of Chemistry and Biochemistry, The University of California, Los Angeles, California, 90095.
Christopher N JohnsonDepartment of Chemistry, Mississippi State University, Starkville, Mississippi, 39759.
Sandor GyörkeThe Dorothy M. Davis Heart and Lung Research Institute, The Ohio State University Wexner Medical Center, Columbus, Ohio, 43210.
Jonathan P DavisThe Dorothy M. Davis Heart and Lung Research Institute, The Ohio State University Wexner Medical Center, Columbus, Ohio, 43210.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Calmodulin (CaM) is a highly conserved Ca

Indexed as

Biological SciencesBiophysics and Computational Biologycalcium signalingcalmodulincardiac physiologyMajorMinormolecular dynamics simulationsprotein engineeringryanodine receptor

Identifiers

PMID42039542
PMCPMC13105089

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.