Evidence map›Paper›PMID 42039526›Full record

ArticlebioRxiv : the preprint server for biology2026

Crystal structure and molecular dynamics simulations of rademikibart Fab-IL-4Rα complex reveal biochemical basis for next-generation potent IL-4Rα inhibition in type 2 allergic and inflammatory diseases.

Yuanjun Shi, Kelsey Nolden, Minh Ho, Haote Li, Victor S Batista, Raúl Collazo, Christopher G Bunick

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Yuanjun ShiDepartment of Chemistry, Yale University, New Haven, CT, USA.ORCID 0000-0002-9240-6950
Kelsey NoldenDepartment of Biochemistry, Medical College of Wisconsin, Milwaukee, WI, USA.ORCID 0000-0003-2235-7900
Minh HoDepartment of Dermatology, Yale School of Medicine, New Haven, CT, USA.ORCID 0000-0001-7192-3919
Haote LiDepartment of Chemistry, Yale University, New Haven, CT, USA.ORCID 0000-0002-8146-5066
Victor S BatistaDepartment of Chemistry, Yale University, New Haven, CT, USA.ORCID 0000-0002-3262-1237
Raúl CollazoConnect Biopharma, San Diego, CA, USA.ORCID 0000-0002-7077-7443
Christopher G BunickDepartment of Dermatology, Yale School of Medicine, New Haven, CT, USA.ORCID 0000-0002-4011-8308

Funding

Molecular function of an intermediate filament assembly mechanism in epidermal protein complexes and cell migrationR01AR079428 · NIAMS · YALE UNIVERSITY · PI BUNICK, CHRISTOPHER GERARD · 2021 to 2025
$1.8M
Studies of Allostery between Multi-domain Proteins and Nucleic Acid ComplexesR01GM136815 · NIGMS · YALE UNIVERSITY · PI BATISTA, VICTOR S · 2021 to 2024
$1.4M
NIAMS NIH HHS R01 AR079428NIGMS NIH HHS R01 GM136815
6 · The paper itself

Abstract

Rademikibart (CBP-201) is a human monoclonal antibody with higher binding affinity to IL-4Rα compared to dupilumab. Dupilumab is a first-generation interleukin-4 receptor alpha (IL-4Rα) inhibitor for treating IL-4Rα-dependent inflammatory disorders, including several dermatologic and respiratory conditions. Rademikibart, however, demonstrated better inhibition of STAT6 intracellular signaling

Indexed as

allergyantibody therapeuticsasthmaatopic dermatitiscytokine and receptor signaling mechanismsdupilumabskin inflammation

Identifiers

PMID42039526
PMCPMC13104862

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.