Evidence map›Paper›PMID 42039524›Full record

ArticlebioRxiv : the preprint server for biology2026

Saturated cardiolipins are potent disruptors of inner mitochondrial membrane structure and function.

Kailash Venkatraman, Daniel Milshteyn, Carolina Sarto, Elida Kocharian, Cailyn M Sakurai, Aaron M Armando, Adrian M Wong, Edward A Dennis, Xi Fang, Christopher T Lee and 1 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Kailash VenkatramanDepartment of Biochemistry & Molecular Biophysics, University of California San Diego, La Jolla, CA 92093, USA.
Daniel MilshteynDepartment of Biochemistry & Molecular Biophysics, University of California San Diego, La Jolla, CA 92093, USA.
Carolina SartoDepartment of Molecular Biology, University of California San Diego, La Jolla, CA, USA.
Elida KocharianDepartment of Biochemistry & Molecular Biophysics, University of California San Diego, La Jolla, CA 92093, USA.
Cailyn M SakuraiDepartment of Molecular Biology, University of California San Diego, La Jolla, CA, USA.
Aaron M ArmandoDepartment of Pharmacology, School of Medicine, University of California San Diego, La Jolla, CA 92093.
Adrian M WongDepartment of Biochemistry & Molecular Biophysics, University of California San Diego, La Jolla, CA 92093, USA.
Edward A DennisDepartment of Biochemistry & Molecular Biophysics, University of California San Diego, La Jolla, CA 92093, USA.
Xi FangDepartment of Medicine, University of California San Diego, La Jolla, CA 92093.
Christopher T LeeDepartment of Molecular Biology, University of California San Diego, La Jolla, CA, USA.ORCID 0000-0002-0670-2308
Itay BudinDepartment of Biochemistry & Molecular Biophysics, University of California San Diego, La Jolla, CA 92093, USA.ORCID 0000-0001-9706-4294

Funding

Training and OutreachP30GM124166 · NIGMS · CORNELL UNIVERSITY · PI RICHARD A. CERIONE · 2019 to 2026
$28.3M
Pathways in Biological Sciences Training ProgramT32GM133351 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Matthew Daugherty, Randolph Y. Hampton · 2020 to 2026
$9.9M
MOLECULAR BIOPHYSICS TRAINING PROGRAMT32GM008326 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI KOMIVES, ELIZABETH A. · 1989 to 2020
$7.5M
Lipidic drivers of organelle function and dysregulationR35GM142960 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Itay Budin · 2021 to 2026
$4.3M
Action of Lipolytic EnzymesR35GM139641 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI EDWARD A DENNIS · 2021 to 2026
$2.6M
Molecular mechanisms and treatment of cardiomyopathy in Barth SyndromeR01HL157115 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI FANG, XI · 2021 to 2025
$2.0M
NHLBI NIH HHS R01 HL157115NIGMS NIH HHS P30 GM124166NIGMS NIH HHS R35 GM139641NIGMS NIH HHS R35 GM142960NIGMS NIH HHS T32 GM008326NIGMS NIH HHS T32 GM133351
6 · The paper itself

Abstract

Cardiolipin (CL) is a four-acyl chained, mitochondrial-specific phospholipid crucial for maintenance of inner mitochondrial membrane (IMM) structure and function. In healthy tissues, CL acyl chains are highly unsaturated and maintained by a conserved remodeling pathway. However, dysregulation of CL acyl chain composition can arise from mutations in the CL transacylase, Tafazzin (TAZ), resulting in Barth syndrome (BTHS), where patients exhibit heightened mitochondrial dysfunction. Cells lacking TAZ accumulate three-acyl chained monolysocardiolipin (MLCL) as well as CL species with saturated acyl chains (CL

Identifiers

PMID42039524
PMCPMC13104832

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.