Evidence map›Paper›PMID 42039521›Full record

ArticlebioRxiv : the preprint server for biology2026

Activity induced GEM-4/Copine expression inhibits gap junctions and promotes thermosensory plasticity.

Luna Gao, Sam Bates, Edward Pym, Stephen Nurrish, Piali Sengupta, Joshua M Kaplan

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Luna GaoDepartment of Molecular Biology, Massachusetts General Hospital, Boston, MA 02114, USA.
Sam BatesDepartment of Biology, MS008, Brandeis University, 415 South Street, Waltham, MA 02454, USA.
Edward PymDepartment of Organismic and Evolutionary Biology, Harvard University, 16 Divinity Ave, Cambridge, MA, 02138, USA.
Stephen NurrishDepartment of Molecular Biology, Massachusetts General Hospital, Boston, MA 02114, USA.
Piali SenguptaDepartment of Biology, MS008, Brandeis University, 415 South Street, Waltham, MA 02454, USA.
Joshua M KaplanDepartment of Molecular Biology, Massachusetts General Hospital, Boston, MA 02114, USA.

Funding

MECHANOTRANSDUCTION IN C ELEGANSR01NS032196 · NINDS · UNIVERSITY OF CALIFORNIA BERKELEY · PI JOSHUA M KAPLAN · 1993 to 2026
$8.6M
Mechanisms of sensory neuron morphological diversification, signaling, and functional plasticityR35GM122463 · NIGMS · BRANDEIS UNIVERSITY · PI Piali Sengupta · 2017 to 2026
$7.7M
Enhancing and expanding the CGC Strain CollectionP40OD010440 · OD · UNIVERSITY OF MINNESOTA · PI Aric L Daul, Ann E. Rougvie · 2012 to 2026
$7.5M
Predoctoral Training in Cross-Disciplinary Molecular and Cellular BiologyT32GM139798 · NIGMS · BRANDEIS UNIVERSITY · PI Paul Garrity, Bruce L Goode · 2021 to 2026
$3.5M
Mechanotransduction in C elegansR37NS032196 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI KAPLAN, JOSHUA M · 2008 to 2014
$2.8M
NIGMS NIH HHS R35 GM122463NIGMS NIH HHS T32 GM139798NIH HHS P40 OD010440NINDS NIH HHS R01 NS032196NINDS NIH HHS R37 NS032196
6 · The paper itself

Abstract

Activity regulated transcription modifies the intrinsic excitability of cells, which is proposed to promote neuronal and behavioral plasticity; however, the transcriptional targets involved have not been identified. Here, we identify a single MEF-2 and CRH-1/CREB transcriptional target,

Indexed as

CREBgap junctionsintrinsic excitabilityMEF2thermosensation

Identifiers

PMID42039521
PMCPMC13104953

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.