Evidence map›Paper›PMID 42039489›Full record

ArticlebioRxiv : the preprint server for biology2026

Mutant KRAS promotes NF-κB driven CCL20 chemokine expression in pancreatic ductal adenocarcinoma.

Donovan Drouillard, Marissa Davies, Donna McAllister, Michael B Dwinell

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Donovan DrouillardDepartment of Microbiology & Immunology; Medical College of Wisconsin, Milwaukee WI, USA.ORCID 0000-0002-2940-3511
Marissa DaviesCenter for Immunology; Medical College of Wisconsin, Milwaukee WI, USA.
Donna McAllisterDepartment of Microbiology & Immunology; Medical College of Wisconsin, Milwaukee WI, USA.
Michael B DwinellDepartment of Microbiology & Immunology; Medical College of Wisconsin, Milwaukee WI, USA.ORCID 0000-0001-5372-633X

Funding

Medical Scientist Training ProgramT32GM080202 · NIGMS · MEDICAL COLLEGE OF WISCONSIN · PI BARBIERI, JOSEPH T, SALZMAN, NITA H · 2010 to 2024
$5.7M
Structure-based inhibition of chemokine signaling in the inflamed pancreasR01DK133247 · NIDDK · MEDICAL COLLEGE OF WISCONSIN · PI Michael B Dwinell, Brian F Volkman · 2023 to 2026
$2.5M
Mechanisms of neutrophil extracellular trap formation and contribution to biliary fibrosis in biliary atresiaR01DK140072 · NIDDK · MEDICAL COLLEGE OF WISCONSIN · PI Michael B Dwinell, CARA LYNN MACK · 2024 to 2026
$2.2M
Targeting the CCR6-CCL20 pathway for treatment of psoriatic joint and entheseal inflammationR44AR081754 · NIAMS · XLOCK BIOSCIENCES, LLC · PI CLARKE, WILLIAM R, VOLKMAN, BRIAN F · 2023 to 2024
$2.0M
The role of CCR6 in Pancreatic Cancer and TregsF30CA291095 · NCI · MEDICAL COLLEGE OF WISCONSIN · PI Donovan G Drouillard · 2024 to 2026
$158k
NCI NIH HHS F30 CA291095NIAMS NIH HHS R44 AR081754NIDDK NIH HHS R01 DK133247NIDDK NIH HHS R01 DK140072NIGMS NIH HHS T32 GM080202
6 · The paper itself

Abstract

The chemokine CCL20 is implicated in inflammation and cancer but has proven challenging to target therapeutically. In this study, we precisely define what cells produce CCL20 in pancreatic inflammation and cancer. Through analysis of single cell RNA data, mutation and copy number signatures, gene methylation, and

Indexed as

chemokineimmune evasiononcogenic KRas

Identifiers

PMID42039489
PMCPMC13105078

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.