ArticlebioRxiv : the preprint server for biology2026
Bacteria-mimetic bioadhesives with multivalent mucoadhesion and drug-compatible delivery.
Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
The ability to adhere to mucus-lined tissues underpins a range of biomedical devices and therapies. However, many existing strategies rely on covalent bonding chemistries and can be unstable, cytotoxic, or incompatible with therapeutics. Here, we present a bacteria-mimetic bioadhesion strategy inspired by Novelty Statement: Bioadhesive designs have drawn inspiration from nature such as mussel-inspired catechol chemistry and gecko-inspired dry adhesion. In contrast, bacterial adhesion mechanisms, despite enabling robust colonization of mucus-lined tissues under demanding conditions, remain largely overlooked. This work introduces a bacteria-mimetic bioadhesion strategy that selectively repurposes a short, non-pathogenic peptide derived from a
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