Evidence map›Paper›PMID 42039477›Full record

ArticlebioRxiv : the preprint server for biology2026

SIRT5 acts in the tumor microenvironment via endothelial cell metabolism to support breast cancer growth.

Anthony M Chen, Issahy Cano, Qian Zhao, Pei-Yin Tsai, Elijah A Bacchus, Sadhan Jana, Irma R Fernandez, Zeribe C Nwosu, Andrew Miller, Joeva Barrow and 3 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Anthony M ChenDepartment of Biomedical and Translational Sciences, Cornell University, Ithaca, NY.ORCID 0000-0003-0753-8607
Issahy CanoMeinig School of Biomedical Engineering, Cornell University, Ithaca, NY.ORCID 0000-0001-9994-149X
Qian ZhaoDepartment of Chemistry, University of Chicago, Chicago, IL.
Pei-Yin TsaiDivision of Nutritional Sciences, Cornell University, Ithaca, NY.ORCID 0000-0001-7132-5986
Elijah A BacchusDepartment of Biomedical and Translational Sciences, Cornell University, Ithaca, NY.
Sadhan JanaDepartment of Chemistry, University of Chicago, Chicago, IL.
Irma R FernandezDepartment of Biomedical and Translational Sciences, Cornell University, Ithaca, NY.ORCID 0000-0003-0063-4612
Zeribe C NwosuDepartment of Molecular Biology and Genetics, Cornell University, Ithaca, NY.ORCID 0000-0003-1641-2045
Andrew MillerDepartment of Population Medicine and Diagnostic Sciences, Cornell University, Ithaca, NY.
Joeva BarrowDivision of Nutritional Sciences, Cornell University, Ithaca, NY.
Hening LinDepartment of Chemistry, University of Chicago, Chicago, IL.ORCID 0000-0002-0255-2701
Esak LeeMeinig School of Biomedical Engineering, Cornell University, Ithaca, NY.ORCID 0000-0002-5328-6677
Robert S WeissDepartment of Biomedical and Translational Sciences, Cornell University, Ithaca, NY.ORCID 0000-0003-3327-1379

Funding

Graduate Training Program in Comparative MedicineT32OD011000 · OD · CORNELL UNIVERSITY · PI Amanda Marjorie DE MESTRE · 2012 to 2026
$5.7M
Regulation of Lymphatic Endothelial Cell Junction and DrainageR01HL165135 · NHLBI · CORNELL UNIVERSITY · PI Esak Lee · 2022 to 2026
$2.5M
Targeting the dependency of cancer cells on the sirtuin SIRT5R01CA223534 · NCI · CORNELL UNIVERSITY · PI CERIONE, RICHARD A., LIN, HENING · 2019 to 2023
$2.3M
NCI NIH HHS R01 CA223534NHLBI NIH HHS R01 HL165135NIH HHS T32 OD011000
6 · The paper itself

Abstract

Triple-negative breast cancer (TNBC) is characterized by aggressive progression and poor prognosis, partly due to abnormal angiogenesis. While the metabolic reprogramming of tumor cells is well characterized, the metabolic regulation of tumor-associated endothelial cells (ECs) remains unclear. Here, we identified the mitochondrial deacylase SIRT5, which has established tumor-promoting roles in TNBC cells, as a key regulator of endothelial metabolic homeostasis and tumor angiogenesis. SIRT5-deficient host mice showed significant defects in supporting the growth of orthotopic SIRT5-proficient mammary tumor transplants, and the resulting neoplasms showed defects in tumor vascularization. In a 3D microfluidic vessel-on-chip model,

Identifiers

PMID42039477
PMCPMC13104928

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.