ArticlebioRxiv : the preprint server for biology2026
Dissecting polycomb complexes for enhanced fetal hemoglobin production.
Paul J Kaminski, Kristen Min, Elizabeth A Traxler, Eugene Khandros, Osheiza Abdulmalik, Bailey Godfrey, Cheryl A Keller, Belinda M Giardine, Ross C Hardison, Junwei Shi and 1 more
Abstract readPreprint
In one paragraphArticle in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
5 · Who and what moneyAuthors and funding
11 authors.
Paul J KaminskiDivision of Hematology, Children's Hospital of Philadelphia, Philadelphia, PA.
Kristen MinDivision of Hematology, Children's Hospital of Philadelphia, Philadelphia, PA.
Elizabeth A TraxlerDivision of Hematology and Oncology, University of Pennsylvania, Philadelphia, PA.
Eugene KhandrosDivision of Hematology, Children's Hospital of Philadelphia, Philadelphia, PA.
Osheiza AbdulmalikDivision of Hematology, Children's Hospital of Philadelphia, Philadelphia, PA.
Bailey GodfreyDivision of Hematology, Children's Hospital of Philadelphia, Philadelphia, PA.
Cheryl A KellerDepartment of Biochemistry and Molecular Biology, Pennsylvania State University, University Park, State College, PA.ORCID 0000-0001-6594-0245 Belinda M GiardineDepartment of Biochemistry and Molecular Biology, Pennsylvania State University, University Park, State College, PA.
Ross C HardisonDepartment of Biochemistry and Molecular Biology, Pennsylvania State University, University Park, State College, PA.ORCID 0000-0003-4084-7516 Junwei ShiDepartment of Cancer Biology, University of Pennsylvania, Philadelphia, PA.
Gerd A BlobelDivision of Hematology, Children's Hospital of Philadelphia, Philadelphia, PA.
Funding
Transcriptional Networks Controlling Erythroid DifferentiationR01DK054937 · NIDDK · CHILDREN'S HOSP OF PHILADELPHIA · PI Gerd A Blobel · 1999 to 2026
$12.8MStem Cell and Transplantation BiologyU54DK106829 · NIDDK · FRED HUTCHINSON CANCER RESEARCH CENTER · PI DEREK L STIREWALT · 2015 to 2026
$9.1MRegulation of Hemoglobin SwitchingR01HL119479 · NHLBI · CHILDREN'S HOSP OF PHILADELPHIA · PI Gerd A Blobel · 2013 to 2026
$8.0MHEMATOPOIESIS TRAINING GRANTT32DK007780 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI TONG, WEI · 1999 to 2023
$6.7MRoles of CBP &PCAF During Hematopoietic DifferentiationR01DK058044 · NIDDK · CHILDREN'S HOSP OF PHILADELPHIA · PI BLOBEL, GERD A · 2002 to 2023
$4.5MTraining CoreTL1DK143326 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI Wei Tong · 2024 to 2026
$2.5MInvestigating the mechanisms of polycomb group protein mediated fetal hemoglobin silencingF30HL178209 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI Paul Kaminski · 2025 to 2026
$110kNHLBI NIH HHS F30 HL178209NHLBI NIH HHS R01 HL119479NIDDK NIH HHS R01 DK054937NIDDK NIH HHS R01 DK058044NIDDK NIH HHS T32 DK007780NIDDK NIH HHS TL1 DK143326NIDDK NIH HHS U54 DK106829
6 · The paper itselfAbstract
Polycomb repressive complexes PRC1 and PRC2 regulate diverse developmental processes, including the fetal-to-adult switch in hemoglobin production, a process whose reversal is a goal for the treatment of sickle cell disease and β-thalassemia. PRC inhibitors show promise for various disorders, but use is limited because of pleiotropic PRC activities. We explored whether fetal hemoglobin (HbF) can be reactivated in adult erythroid cells by selective perturbations of PRC1 or PRC2 components without complete loss of PRC function. A high-density CRISPR-Cas9 mutagenesis screen identified a region in the
Identifiers
PMID42039476
PMCPMC13104972
What OpenQuestion holds
Textmetadata
LicenceCC BY-NC
Read underepoch 390