Evidence map›Paper›PMID 42039454›Full record

ArticlebioRxiv : the preprint server for biology2026

Tissue-specific adaptation of human T cells is preserved during tissue inflammation.

Nicole B Potchen, Hugh R MacMillan, Eva Domenjo-Vila, Andrew J Konecny, Alexis K Taber, Caitlin S DeJong, Geervani Daggupati, Swati Shree, Stephen A McCartney, Shelton W Wright and 3 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Nicole B PotchenVaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, WA, USA.ORCID 0000-0003-0699-8863
Hugh R MacMillanVaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, WA, USA.
Eva Domenjo-VilaVaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, WA, USA.
Andrew J KonecnyVaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, WA, USA.
Alexis K TaberVaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, WA, USA.
Caitlin S DeJongVaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, WA, USA.
Geervani DaggupatiVaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, WA, USA.
Swati ShreeDivision of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, University of Washington, Seattle, WA, USA.
Stephen A McCartneyDivision of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, University of Washington, Seattle, WA, USA.ORCID 0000-0003-1102-6778
Shelton W WrightDivision of Pediatric Critical Care Medicine, Department of Pediatrics, University of Washington, Seattle, WA, USA.
Evan W NewellVaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, WA, USA.
Douglas R DixonDepartment of Bioscience Research and Periodontics, University of Tennessee Health Science Center, College of Dentistry, Memphis, TN, USA.
Martin PrlicVaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, WA, USA.ORCID 0000-0002-0685-9321

Funding

Inflammation-driven T Cell Responses and their Dichotomous Effect on Host ImmunityR01AI123323 · NIAID · FRED HUTCHINSON CANCER RESEARCH CENTER · PI PRLIC, MARTIN · 2017 to 2025
$5.0M
Metabolite- and cytokine-mediated signals interact to control human CD8 T cell responses in tissuesR01AI179712 · NIAID · FRED HUTCHINSON CANCER CENTER · PI Jennifer M Lund, Martin Prlic · 2025 to 2026
$1.7M
The role of tissue-resident T cells in resolving inflammation of the human oral mucosaR56DE032009 · NIDCR · FRED HUTCHINSON CANCER CENTER · PI DIXON, DOUGLAS RAYMOND, PRLIC, MARTIN · 2022 to 2022
$615k
NIAID NIH HHS R01 AI123323NIAID NIH HHS R01 AI179712NIDCR NIH HHS R56 DE032009
6 · The paper itself

Abstract

T cells play an essential role in protecting tissues against pathogens and regulating tissue homeostasis. Previous studies highlight that T cells display tissue-specific phenotypic and functional properties, suggesting that T cells adapt to their local environment. Whether inflammation disrupts tissue-specific T cell adaptation remains poorly understood. To address this open question, we examined the T cell compartment - including conventional CD4 and CD8 T cells, regulatory T cells, γδ T cells, and MAIT cells - from healthy and inflamed human mucosal tissues. Using high-parameter spectral flow cytometry, we examined phenotype

Identifiers

PMID42039454
PMCPMC13105066

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.