Evidence map›Paper›PMID 42039446›Full record

ArticlebioRxiv : the preprint server for biology2026

FOXP-stabilization of the

Dachuan Dong, Lauren E Higdon, Jiayan Zhou, Jian-Xin Lin, Jyothi Padiapu, Yesl Kim, Warren J Leonard, Jonathan S Maltzman

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Dachuan DongGeriatric Research Education and Clinical Center, Veterans Administration Palo Alto Health Care System, Palo Alto, California, USA.ORCID 0000-0002-5443-5304
Lauren E HigdonGeriatric Research Education and Clinical Center, Veterans Administration Palo Alto Health Care System, Palo Alto, California, USA.ORCID 0000-0002-6470-6155
Jiayan ZhouPalo Alto Epidemiology Research and Information Center for Genomics, Veterans Administration Palo Alto Health Care System, Palo Alto, California, USA.ORCID 0000-0001-5974-087X
Jian-Xin LinLaboratory of Molecular Immunology and the Immunology Center, National Heart, Lung, and Blood Institute, NIH, Bethesda, USA.ORCID 0000-0001-5849-9412
Jyothi PadiapuLaboratory of Molecular Immunology and the Immunology Center, National Heart, Lung, and Blood Institute, NIH, Bethesda, USA.ORCID 0000-0002-9507-6133
Yesl KimGeriatric Research Education and Clinical Center, Veterans Administration Palo Alto Health Care System, Palo Alto, California, USA.
Warren J LeonardLaboratory of Molecular Immunology and the Immunology Center, National Heart, Lung, and Blood Institute, NIH, Bethesda, USA.ORCID 0000-0002-5740-7448
Jonathan S MaltzmanGeriatric Research Education and Clinical Center, Veterans Administration Palo Alto Health Care System, Palo Alto, California, USA.ORCID 0000-0001-5722-269X

Funding

Foxp transcription factors in regulatory T cell development and homeostasisR56AI108786 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI MALTZMAN, JONATHAN S · 2014 to 2014
$396k
BLRD VA I01 BX005142Intramural NIH HHS Z99 HL999999NIAID NIH HHS R56 AI108786
6 · The paper itself

Abstract

Gene expression in regulatory T cells (Tregs) is context-dependent and maintains peripheral immune homeostasis. FOXP3 is lineage defining but not sufficient for Treg function or persistence. To define the cell-intrinsic roles of the FOXP3 paralogs FOXP1 and FOXP4, we generated and studied mice with Treg-specific deletion of

Identifiers

PMID42039446
PMCPMC13105002

What OpenQuestion holds

Textmetadata
LicenceCC0
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.