Evidence map›Paper›PMID 42039436›Full record

ArticlebioRxiv : the preprint server for biology2026

Loss of Propionyl-CoA Carboxylase Reprograms Hepatic Metabolism by Suppressing Mitochondrial Pyruvate Carboxylation and Fatty Acid Oxidation.

Fang Lu, Chorlada Paiboonrungruang, Wentao He, Zhaohui Xiong, Pingchuan Tang, Takhar Kasumov, Xiaoxin Chen, Guo-Fang Zhang

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Fang LuSarah W. Stedman Nutrition and Metabolism Center & Duke Molecular Physiology Institute, Duke University, Durham, NC 27701, USA.
Chorlada PaiboonrungruangCoriell Institute for Medical Research, Camden, NJ 08103, USA.
Wentao HeSarah W. Stedman Nutrition and Metabolism Center & Duke Molecular Physiology Institute, Duke University, Durham, NC 27701, USA.
Zhaohui XiongCoriell Institute for Medical Research, Camden, NJ 08103, USA.
Pingchuan TangSarah W. Stedman Nutrition and Metabolism Center & Duke Molecular Physiology Institute, Duke University, Durham, NC 27701, USA.
Takhar KasumovDepartment of Pharmaceutical Sciences, College of Pharmacy, Northeast Ohio Medical University, Rootstown, Ohio, USA.
Xiaoxin ChenCoriell Institute for Medical Research, Camden, NJ 08103, USA.
Guo-Fang ZhangSarah W. Stedman Nutrition and Metabolism Center & Duke Molecular Physiology Institute, Duke University, Durham, NC 27701, USA.

Funding

Triacetin Treatment for Propionic Acidemia by Rebalancing the Acetyl-CoA/Propionyl-CoA MetabolismR21TR005163 · NCATS · DUKE UNIVERSITY · PI CHEN, XIAOXIN LUKE, ZHANG, GUOFANG · 2024 to 2025
$431k
NCATS NIH HHS R21 TR005163
6 · The paper itself

Abstract

Propionic acidemia (PA) is an inborn error of metabolism caused by propionyl-CoA carboxylase (PCC) deficiency due to mutations in either

Indexed as

branched-chain amino acidsfatty acid oxidationmetabolic flux analysisPCCAnull-HepG2propionatePropionic acidemiapyruvate carboxylationstable isotope

Identifiers

PMID42039436
PMCPMC13104956

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.