ArticlebioRxiv : the preprint server for biology2026
Ancient DNA reveals that natural selection has upregulated the immune system over the last 10,000 years.
Javier Maravall-López, Buu Truong, Gaspard Kerner, Yujie Zhao, Kangcheng Hou, Annabel Perry, Ali Akbari, David Reich, Alkes L Price
Abstract readPreprint
In one paragraphArticle in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
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3 · Its place in the literatureWho cites it
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4 · The recordCorrections and comments
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5 · Who and what moneyAuthors and funding
9 authors.
Javier Maravall-LópezDepartment of Human Evolutionary Biology, Harvard University, Cambridge, MA, USA.ORCID 0009-0003-4970-5976 Yujie ZhaoDepartment of Epidemiology, Harvard School of Public Health, Boston, MA, USA.
Kangcheng HouDepartment of Epidemiology, Harvard School of Public Health, Boston, MA, USA.
Annabel PerryDepartment of Human Evolutionary Biology, Harvard University, Cambridge, MA, USA.
Ali AkbariDepartment of Human Evolutionary Biology, Harvard University, Cambridge, MA, USA.
David ReichDepartment of Human Evolutionary Biology, Harvard University, Cambridge, MA, USA.
Alkes L PriceDepartment of Epidemiology, Harvard School of Public Health, Boston, MA, USA.
Funding
Statistical methods for studies of rare variantsR01MH101244 · NIMH · HARVARD MEDICAL SCHOOL · PI Benjamin Michael Neale, ALKES L PRICE · 2013 to 2026
$9.4MStatistical methods to localize disease heritability and identify biological mechanismsR37MH107649 · NIMH · BROAD INSTITUTE, INC. · PI Benjamin Michael Neale · 2019 to 2026
$7.0MMethods for Genome-wide Association Studies in Admixed PopulationsR01HG006399 · NHGRI · HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH · PI PRICE, ALKES L · 2011 to 2024
$6.3MJoint genomic and statistical analyses of schizophrenia and bipolar to decipher genetic susceptibilityR01MH115676 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Roel A Ophoff, Bogdan Pasaniuc · 2018 to 2026
$5.9MPredicting the impact of genetic variants, genes and pathways on human DiseaseU01HG012009 · NHGRI · BRIGHAM AND WOMEN'S HOSPITAL · PI ALKES L PRICE, Soumya Raychaudhuri · 2021 to 2026
$4.2MSolving ascertainment bias in ancient DNA using Ultima Genomics sequencingR01HG012287 · NHGRI · HARVARD MEDICAL SCHOOL · PI REICH, DAVID E · 2021 to 2025
$2.7MIntegrative modelling of single-cell data to elucidate the genetic architecture of complex diseaseR01HG013083 · NHGRI · DANA-FARBER CANCER INST · PI ALEXANDER GUSEV, ALKES L PRICE · 2024 to 2026
$1.5MNHGRI NIH HHS R01 HG006399NHGRI NIH HHS R01 HG012287NHGRI NIH HHS R01 HG013083NHGRI NIH HHS U01 HG012009NIMH NIH HHS R01 MH101244NIMH NIH HHS R01 MH115676NIMH NIH HHS R37 MH107649
6 · The paper itselfAbstract
The specific mechanisms through which human biology and disease susceptibility evolved with major shifts in West Eurasian environments and societies over the last 10,000 years(
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PMCPMC13104968
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