Evidence map›Paper›PMID 42039388›Full record

ArticlebioRxiv : the preprint server for biology2026

Parkinson's disease-linked D620N mutation selectively alters the brain-specific protein interactome of VPS35.

Erin T Williams, Xi Chen, Jordan Rowlands, Md Shariful Islam, Maxwell Frye, Darren J Moore

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Erin T WilliamsDepartment of Neurodegenerative Science, Van Andel Institute, Grand Rapids, MI 49503, USA.
Xi ChenDepartment of Neurodegenerative Science, Van Andel Institute, Grand Rapids, MI 49503, USA.
Jordan RowlandsDepartment of Neurodegenerative Science, Van Andel Institute, Grand Rapids, MI 49503, USA.
Md Shariful IslamDepartment of Neurodegenerative Science, Van Andel Institute, Grand Rapids, MI 49503, USA.
Maxwell FryeWest Michigan Neurodegenerative Diseases (MiND) Program, Van Andel Institute, Grand Rapids, MI 49503, USA.
Darren J MooreDepartment of Neurodegenerative Science, Van Andel Institute, Grand Rapids, MI 49503, USA.ORCID 0000-0003-2359-5679

Funding

Exploring mechanisms of Parkinson's disease-linked D620N VPS35 in rat modelsR01NS117137 · NINDS · VAN ANDEL RESEARCH INSTITUTE · PI MOORE, DARREN JOHN · 2020 to 2024
$2.2M
Mechanisms of VPS35-Dependent Neurodegeneration in Parkinson's DiseaseR01NS105432 · NINDS · VAN ANDEL RESEARCH INSTITUTE · PI MOORE, DARREN JOHN · 2017 to 2021
$2.1M
NINDS NIH HHS R01 NS105432NINDS NIH HHS R01 NS117137
6 · The paper itself

Abstract

Mutations in several genes are known to cause familial forms of Parkinson's disease (PD), including mutations in the

Identifiers

PMID42039388
PMCPMC13105075

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.