ReviewFrontiers in cardiovascular medicine2026
The causal role of genetically predicted obesity-related traits in heart failure: systematic review and meta-analysis of Mendelian randomization studies.
Review in Frontiers in cardiovascular medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
11 authors.
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Abstract
Background: Obesity is a major public health concern and has been implicated in the pathogenesis of heart failure (HF). However, the causal nature of this relationship remains to be comprehensively elucidated through robust genetic epidemiological approaches. Objective: This systematic review and meta-analysis aimed to synthesize evidence from Mendelian randomization (MR) studies regarding the causal effects of genetically predicted obesity and related anthropometric traits on HF and its subtypes. Methods: A comprehensive literature search was conducted across PubMed, Google Scholar, Web of Science, Embase, and the Cochrane Library for studies published up to October 2025. Study quality was assessed, and random-effects meta-analysis were performed where applicable. Result: Genetically predicted adult BMI was significantly associated with increased HF risk across European (OR Conclusion: This study provides robust MR evidence supporting a causal role of multiple obesity-related traits, particularly adult BMI, in the development of HF across diverse populations. Further MR studies in non-European populations and investigations into specific pathways are warranted to enhance generalizability and mechanistic understanding. Systematic Review Registration: crd.york.ac.uk/PROSPERO/display_record.php?RecordID=576216 identifier, CRD42024576216.
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