ReviewInternational journal of dentistry2026
Lipopolysaccharides Modulate Cellular Responses in Dental Pulp Cells.
Review in International journal of dentistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- An innate defense regulator peptide modulates the inflamed pulp microenvironment and promotes pulp repair.Bioactive materials · 2026Article
- Lipopolysaccharides Modulate Cellular Responses in Dental Pulp Cells.International journal of dentistry · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Lipopolysaccharide (LPS) triggers signal transduction in dental pulp cells (DPCs), leading to various biological events. The present study described the biological response of DPCs to LPS, aiming to provide a deeper understanding of its mechanisms. A literature search was performed in PubMed, Web of Science and Google Scholar using the keywords 'lipopolysaccharide', 'dental pulp cells' and 'dental pulp stem cells'. Original studies and review articles published in English that investigated cellular or molecular responses of pulp-derived cells to LPS stimulation were included. A narrative review was then conducted to summarise and discuss the effects of LPS on these cells. Across the selected studies, LPS exposure consistently activates intracellular signalling cascades in DPCs, leading to a series of downstream events, including inflammatory cytokine production, oxidative stress generation, mitochondrial impairment, premature cellular senescence and alterations in odonto/osteogenic differentiation. These interconnected molecular changes underpin the progression of pulpal inflammation and influence the tissue's capacity for repair or regeneration. This narrative review described the biological response of DPCs to LPS, providing deeper insight into its mechanisms. Understanding LPS-mediated signalling enables clinicians to tailor regenerative therapeutic approaches and vital pulp therapies by modulating inflammation and optimising biological events to support dental pulp tissue healing and dentine regeneration.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.