ArticleEthiopian journal of health sciences2026
Epidemiology and Clinical Profile of Aspergillus Hypersensitivity and Allergic Bronchopulmonary Aspergillosis in Children with Asthma: A Hospital-Based Study.
Article in Ethiopian journal of health sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: The aim of this study was to examine the prevalence of Aspergillus sensitivity (AS) and allergic bronchopulmonary aspergillosis (ABPA) in children with Bronchial Asthma. Methods: The study included 200 children with bronchial asthma. ABPA was diagnosed using Aspergillus skin testing, pulmonary function testing, absolute eosinophil count, total serum IgE, Aspergillus-specific IgE and IgG, chest radiography, and high-resolution computed tomography. Patients were diagnosed and classified according to the Rosenberg-Patterson criteria for ABPA. Results: Of the 200 children with bronchial asthma, 7 patients were ABPA positive. Among the ABPA-positive cases, 5 (71.4%) had uncontrolled asthma. The mean absolute eosinophil count (AEC) was significantly higher in ABPA-positive cases (418.71 ± 90.12 cells/cumm). The mean total serum IgE in positive cases was 1181.00 ± 403.42 IU/L. The mean Aspergillus-specific IgE level in positive cases was 4.74 ± 6.09 kUA/L. In ABPA-positive cases, the mean Aspergillus-specific IgG level was 26.06 ± 14.93 mgA/L. Conclusion: This study demonstrated an association between ABPA and bronchial asthma in children. ABPA is a common entity in bronchial asthma and should be considered as a cause of uncontrolled asthma when symptoms persist despite the use of multiple medications.
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