ArticleEthiopian journal of health sciences2026
Assessment of Apparent Diffusion Coefficient and Perfusion Values of the Placenta in Intrauterine Growth Restriction by Using 3Tesla Magnetic Resonance Imaging (MRI) in an Indian Population: A Pilot Study.
Article in Ethiopian journal of health sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Intrauterine growth restriction (IUGR) is defined as an estimated fetal weight below the 10th percentile for gestational age and is commonly associated with placental insufficiency and abnormal fetoplacental oxygenation. This study aimed to assess placental apparent diffusion coefficient (ADC) and perfusion values in IUGR using 3T magnetic resonance imaging (MRI). Methods: Sixty pregnant women (30 with IUGR and 30 controls; gestational age 20-38 weeks) underwent placental MRI on a 3T system. The imaging protocol included T2-weighted anatomical sequences, diffusion-weighted imaging (b-values: 0 and 700 s/mm Results: Mean placental perfusion was significantly lower in the IUGR group compared with controls (102.5 ± 18.7 vs. 120.2 ± 23.7 ml/100 g/min, p = 0.002). ADC values were also significantly reduced in IUGR placentas (1.83 ± 0.10 × 10 Conclusion: Both placental ADC and perfusion values were reduced in IUGR. However, because ADC is influenced by perfusion bias, the most clinically relevant finding is the direct quantification of reduced placental perfusion using 3D pCASL at 3T. This technique provides absolute perfusion values in physiological units and may serve as a valuable non-invasive biomarker of placental dysfunction in IUGR.
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