Evidence map›Paper›PMID 42039295›Full record

ArticleActa pharmaceutica Sinica. B2026

Deep eutectic solvents@enteric technology for orally delivering anticoagulant macromolecule drug.

Xiaoke He, Jiahui Zou, Yuxin Jiang, Runrui Liao, Huiling Liao, Yaping Liu, Yueming Zhao, Jing Yu, Wei He

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Acta pharmaceutica Sinica. B, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Xiaoke HeDepartment of Pharmaceutics, School of Pharmacy, China Pharmaceutical University, Nanjing 211198, China.
Jiahui ZouDepartment of Pharmaceutics, School of Pharmacy, China Pharmaceutical University, Nanjing 211198, China.
Yuxin JiangDepartment of Pharmaceutics, School of Pharmacy, China Pharmaceutical University, Nanjing 211198, China.
Runrui LiaoDepartment of Pharmaceutics, School of Pharmacy, China Pharmaceutical University, Nanjing 211198, China.
Huiling LiaoDepartment of Pharmaceutics, School of Pharmacy, China Pharmaceutical University, Nanjing 211198, China.
Yaping LiuDepartment of Pharmaceutics, School of Pharmacy, China Pharmaceutical University, Nanjing 211198, China.
Yueming ZhaoDepartment of Respiratory and Critical Medicine, Nanjing First Hospital, Nanjing Medical University, Nanjing 210000, China.
Jing YuDepartment of Clinical Pharmacy, The First Hospital of Hebei Medical University, Shijiazhuang 050000, China.
Wei HeShanghai Skin Disease Hospital, Tongji University School of Medicine, Shanghai 200443, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Low-molecular-weight heparin (LMWH) is one of the most clinically used anticoagulants to improve venous circulation. However, LMWH requires repeated injections, leading to poor medication compliance. Herein, we developed a deep eutectic solvents (DESs)@enteric technology, an intestinal absorption promotion platform, for the oral administration of LMWH. DESs with geranic acid (Ge) and choline (Ch) were first synthesized and characterized. Then, the DES-LMWH complex was prepared with a DES

Indexed as

Absorption enhancersAnticoagulantDeep eutectic solventsEnteric capsuleLow molecular weight heparinMacromolecule drugOral administrationVenous thromboembolism

Identifiers

PMID42039295
PMCPMC13104645

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.