ReviewActa pharmaceutica Sinica. B2026
Cuproptosis-based nanomedicine in cancer metastasis synergistic therapy.
Review in Acta pharmaceutica Sinica. B, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
5 citing papers in PubMed.
- Engineering cuproptosis with nanomedicine: Design, combination therapy, and translation in cancer.Materials today. Bio · 2026Review
- Editorial of special column of hot topic reviews in drug delivery (II).Acta pharmaceutica Sinica. B · 2026Article
- Mechanistic inhibition of FtsZ-driven bacterial cytokinesis by natural products: an integrated machine learning and advanced drug discovery approach.Molecular diversity · 2026Article
- Copper and cuproptosis-related genes as indictors for the diagnosis of injury time in traumatic brain injury: human cases and animal experiment.Frontiers in cellular neuroscience · 2026Article
- Editorial: Cuproptosis and tumors, volume II: from basic research to clinical translation.Frontiers in cell and developmental biology · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cancer metastasis is a critical indicator of cancer progression and serves as a major cause of cancer-related deaths. Cuproptosis is a novel form of regulated cell death proposed in 2022. Unlike ferroptosis and other known regulated cell deaths (RCDs), cuproptosis has a unique regulatory pathway, and its major biochemical features include copper overload, lipoylated tricarboxylic acid cycle protein aggregation, and the loss of iron-sulfur cluster protein. Cuproptosis-based nanomedicine provides novel therapeutic insights for metastatic cancer treatment. The close link between cuproptosis and cancer therapy has been explored, and several therapeutic strategies have been developed, including copper ionophores and drug delivery systems. Cuproptosis-based nanotherapeutic strategies may enable controlled and selective drug release, and through the multifaceted actions of copper metallocompounds, achieve multimodal theranostic modalities or organically synergize with other regulated RCD pathways. This integration enhances antitumor effects and biosafety, overcomes tumor resistance, and improves the tumor microenvironment. In this review, we systematically delineate the mechanisms of cuproptosis and its current therapeutic implications in metastatic malignancies. We further critically analyze these synergistic therapeutic approaches, prospect emerging applications of cuproptosis-based nanomedicine in metastatic oncology, and highlight their untapped therapeutic potential. Ultimately, we anticipate this exploration will inform innovative clinical management strategies for cancer patients with metastasis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.