ArticleRSC advances2026
Synthesis, and evaluation of novel low nanomolar isoindigo-based RET kinase inhibitors.
Article in RSC advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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4 authors.
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Abstract
Acquired resistance to selective kinase inhibitors remains a primary challenge in targeted cancer therapy. The clinical efficacy of potent rearranged during transfection (RET) inhibitors, for instance, is often attenuated by the emergence of on-target mutations, such as the V804L gatekeeper variant. To address this, a novel series of isoindigo-based compounds were designed, synthesized, and evaluated for RET kinase inhibitory activity. This effort led to the identification of compound 4c, which demonstrated potent, low-nanomolar inhibition of wild-type RET kinase (IC
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