ArticleIranian journal of medical sciences2026
Discovery of Biomarkers Related to Colorectal Cancer by Systematic Proteomics Analysis and Experimental Procedures.
Article in Iranian journal of medical sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Long non-coding RNAs (lncRNAs) play critical roles in gene expression regulation and have emerged as potential biomarkers for cancer diagnosis and treatment. This study aimed to investigate the potential role of two lncRNAs, LINC00943 and SLC9A3-AS1, as candidate biomarkers for colorectal cancer (CRC) diagnosis and therapy. Methods: Initially, we investigated differentially expressed proteins (DEPs) in CRC through a comprehensive bioinformatics analysis and constructed a multi-layer regulatory network to understand the complex interactions. Subsequently, tissue samples were collected from CRC patients at Milad Hospital in Isfahan, Iran, between June and December 2021. The expression levels of LINC00943 and SLC9A3-AS1 were evaluated using quantitative reverse transcription polymerase chain reaction (qRT-PCR). Statistical analyses were performed using GraphPad Prism version 9. Expression differences between tumor and adjacent non-tumor tissues were evaluated using paired Student's Results: Conclusion: These findings suggest that
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