ArticleFrontiers in immunology2026
B-cell DNA methylation signature in response to hepatitis B virus vaccination in females and males.
Article in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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13 authors.
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Abstract
Introduction: Sex-based differences in immune responses to vaccination are well-documented, yet the underlying epigenetic mechanisms remain poorly understood. This study investigates DNA methylation profiles in B cells following hepatitis B virus (HBV) vaccination, with a focus on sex-specific patterns. Methods: Using high-resolution genome-wide methylation analysis, we examined post-vaccination samples from healthy male and female health care workers. Results: Our results reveal distinct methylation signatures associated with vaccine response, with several loci showing sex-dependent differential methylation. Pathway analysis identified immune-related genes and regulatory elements potentially involved in B cell activation and memory formation. Our findings show that DNA methylation levels differ between responders versus non-responders to HBV vaccination and these alterations vary with biological sex. Discussion: Understanding these epigenetic variations may open new perspective on vaccination practice. Collecting data on B cell epigenetics in different vaccination protocols could improve our knowledge on immunization function and contribute to more personalized vaccination strategies.
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