Evidence map›Paper›PMID 42039157›Full record

ReviewFrontiers in immunology2026

Advances in IL-15-Based Cancer Immunotherapy and Divergent Immunological Effects of IL-2 and IL-15 Signaling via the Shared IL-2Rβγ Receptor.

Huiquan Gao, Tao Ma, Qinqin Jiang, Lanfang Gao, Jinfang Li, Shubo Wang, Ziyong Liu, Zhixin Zhang, Gang Wu, Wenxin He and 1 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Huiquan Gao *Department of Radiotherapy, The Affiliated Yantai Yuhuangding Hospital of Qingdao University, Yantai, China.
Tao Ma *Department of Thoracic Surgery, The 970th Hospital of the People's Liberation Army, Weihai, Shandong, China.
Qinqin Jiang *Department of Thoracic Surgery, The 970th Hospital of the People's Liberation Army, Weihai, Shandong, China.
Lanfang Gao *Department of Thoracic Surgery, The 970th Hospital of the People's Liberation Army, Weihai, Shandong, China.
Jinfang Li *Department of Ultrasound, Weihai Municipal Hospital, Weihai, Shandong, China.
Shubo Wang *Department of Gynecology, The Affiliated Weihai Second Municipal Hospital of Qingdao University, Weihai, Shandong, China.
Ziyong LiuDepartment of Thoracic Surgery, The 970th Hospital of the People's Liberation Army, Weihai, Shandong, China.
Zhixin ZhangDepartment of Thoracic Surgery, The 970th Hospital of the People's Liberation Army, Weihai, Shandong, China.
Gang WuBioinformatics and Molecular Genetics, Faculty of Biology, University of Freiburg, Freiburg, Germany.
Wenxin HeDepartment of Thoracic Surgery, Shanghai Pulmonary Hospital, School of Medicine, Tongji University, Shanghai, China.
Fuxin ZhouDepartment of General and Visceral Surgery, Faculty of Medicine, Medical Center - University of Freiburg, Freiburg, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Interleukin-15 (IL-15) has emerged as a central cytokine for next-generation cancer immunotherapy because of its unique ability to sustain the survival, proliferation, and cytotoxic function of memory CD8

Indexed as

ImmunotherapyInterleukin-15Interleukin-2Interleukin-2 Receptor beta SubunitInterleukin Receptor Common gamma SubunitNeoplasmsAnimalsHumansSignal TransductionInterleukin-15Interleukin-2Interleukin-2 Receptor beta SubunitInterleukin Receptor Common gamma Subunitcancer immunotherapyCAR-NK cellsCAR-T cellscytokine engineeringimmune checkpoint inhibitor (ICI)immunocytokinesinterleukin-15 (IL-15)interleukin-2 (IL-2)

Identifiers

PMID42039157
PMCPMC13106419

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.