ArticleJournal of bioactive and compatible polymers2026
PH-responsive hydrolysis of salicylate-based polyanhydride copolymer fibers for targeted drug delivery.
Article in Journal of bioactive and compatible polymers, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Periodontitis is a chronic inflammatory condition that leads to tissue damage, bone loss, and gingival recession. In this disease, pH levels in the mouth are affected by food and saliva as well as tissue inflammation and damage caused by periodontitis. Monitoring pH levels helps assess disease progression and treatment outcomes; therefore, it is important to study the degradation of the biomaterials under relevant pH conditions. Fibers are valuable in treating periodontal disease by enabling site-specific drug delivery to affected soft and hard tissues. In this work, we evaluate polyanhydride fibers that undergo hydrolysis to yield salicylic acid as a function of pH conditions. The physical properties of the polyanhydrides, specifically those based on ester-containing carboxyphenoxydecanoate (CPD), can be altered by copolymerization with ether-containing
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