Evidence map›Paper›PMID 42039145›Full record

ReviewFrontiers in cell and developmental biology2026

GPCRs as key regulators in wound healing.

Haidi Chen, Kun Zheng, Yue Xiao, Xun Feng, Chang Zhang, Ting Zhang, Feng Luo, Huangyu Chuan, Huaping Zheng, Cheng Deng and 1 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Frontiers in cell and developmental biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Haidi Chen *Center for High Altitude Medicine, Institute of High-Altitude Medicine, High Altitude Medicine Key Laboratory of Sichuan Province, Department of Dermatology and Venerology, National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, Chengdu, China.
Kun Zheng *Center for High Altitude Medicine, Institute of High-Altitude Medicine, High Altitude Medicine Key Laboratory of Sichuan Province, Department of Dermatology and Venerology, National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, Chengdu, China.
Yue XiaoDepartment of Dermatology and Venerology, Rare Diseases Center, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Xun FengDepartment of Dermatology and Venerology, Rare Diseases Center, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Chang ZhangCenter for High Altitude Medicine, Institute of High-Altitude Medicine, High Altitude Medicine Key Laboratory of Sichuan Province, Department of Dermatology and Venerology, National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, Chengdu, China.
Ting ZhangCenter for High Altitude Medicine, Institute of High-Altitude Medicine, High Altitude Medicine Key Laboratory of Sichuan Province, Department of Dermatology and Venerology, National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, Chengdu, China.
Feng LuoDepartment of General Dentistry, West China School of Stomatology, Sichuan University, Renmin Nanlu, Chengdu, China.
Huangyu ChuanHarmful Components and Tar Reduction in Tobacco Key Laboratory of Sichuan Province, Chengdu, China.
Huaping ZhengCenter for High Altitude Medicine, Institute of High-Altitude Medicine, High Altitude Medicine Key Laboratory of Sichuan Province, Department of Dermatology and Venerology, National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, Chengdu, China.
Cheng DengCenter for High Altitude Medicine, Institute of High-Altitude Medicine, High Altitude Medicine Key Laboratory of Sichuan Province, Department of Dermatology and Venerology, National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, Chengdu, China.
Wei LiCenter for High Altitude Medicine, Institute of High-Altitude Medicine, High Altitude Medicine Key Laboratory of Sichuan Province, Department of Dermatology and Venerology, National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, Chengdu, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Wound healing is a complex tissue repair process that occurs through a series of overlapping phases, regulated by various cell types and corresponding signaling molecules, including G-protein-coupled receptors (GPCRs). GPCRs are a large family of cell surface receptors that respond to a variety of external signals and significant targets in the design of novel drugs for a wide range of human diseases. They play vital roles throughout the different stages of wound healing. Specifically, GPCRs are essential for the recruitment of immune cells and the activation of signaling cascades related to epidermal cell proliferation and differentiation, including Hedgehog-GLI, Hippo-YAP1, and Wnt/β-catenin pathways. Modifying GPCR activity through agonists or antagonists can alter GPCR signaling pathways, potentially affecting immune cell infiltration, the production of inflammatory mediators, and wound healing rates. This review summarizes the fundamental mechanisms of GPCR signaling pathways in wound healing and highlights recent discoveries regarding the roles and functions of GPCRs in this process.

Indexed as

cell proliferationGPCRinflammationtissue repairwound healing

Identifiers

PMID42039145
PMCPMC13106562

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.