Evidence map›Paper›PMID 42039123›Full record

ArticleFrontiers in endocrinology2026

Association of lower serum and follicular fluid vitamin D levels with reduced fertilization rates in IVF patients with diminished ovarian reserve.

Aiping Zhang, Yanjun Shi, Yuzi Li, Xiaolong Li, Feifei Xu, Qianqian Hong, Feng Yue, Bin Wang, Haofei Shen, Xuehong Zhang

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In one paragraph

Article in Frontiers in endocrinology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Aiping ZhangThe First Clinical Medical College, Lanzhou University, Lanzhou, Gansu, China.
Yanjun ShiSchool of Public Health, Lanzhou University, Lanzhou, Gansu, China.
Yuzi LiThe First Clinical Medical College, Lanzhou University, Lanzhou, Gansu, China.
Xiaolong LiDepartment of Laboratory Medicine, The First Hospital of Lanzhou University, Lanzhou, Gansu, China.
Feifei XuThe First Hospital of Lanzhou University, Lanzhou, Gansu, China.
Qianqian HongClinical Medicine, First Clinical Medical College, Gansu University of Traditional Chinese Medicine, Lanzhou, Gansu, China.
Feng YueThe First Hospital of Lanzhou University, Lanzhou, Gansu, China.
Bin WangThe First Hospital of Lanzhou University, Lanzhou, Gansu, China.
Haofei ShenThe First Hospital of Lanzhou University, Lanzhou, Gansu, China.
Xuehong ZhangThe First Clinical Medical College, Lanzhou University, Lanzhou, Gansu, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: This study aimed to investigate the association between 25-hydroxyvitamin D [25(OH)D] levels in serum (VD-S) and follicular fluid (VD-FF) and the laboratory outcomes of Methods: This prospective cohort study enrolled 145 women undergoing IVF, comprising 74 patients with DOR and 71 with normal ovarian reserve (NOR) as controls. VD-S and VD-FF levels were measured. The DOR group was further stratified into vitamin D (VD) non-deficient (VDH) and VD deficient (VDL) subgroups. Baseline characteristics and IVF laboratory outcomes were compared between the groups and subgroups. Results: A significant positive correlation was observed between VD-S and VD-FF levels (r = 0.769, Conclusion: In patients with diminished ovarian reserve, higher 25(OH)D levels in serum and follicular fluid are positively associated with higher oocyte retrieval and normal fertilization rates during IVF cycles. These findings suggest that VD deficiency may be a modifiable factor associated with IVF outcomes in this specific population.

Indexed as

Fertilization in VitroFollicular FluidInfertility, FemaleOvarian ReserveVitamin DVitamin D DeficiencyAdultFemaleHumansPregnancyPregnancy RateProspective Studies25-hydroxyvitamin DVitamin Ddiminished ovarian reservefollicular fluidin vitro fertilizationserumvitamin D

Identifiers

PMID42039123
PMCPMC13106542

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.