Evidence map›Paper›PMID 42039096›Full record

ArticleNetwork neuroscience (Cambridge, Mass.)2026

Structure-function multilayer network integration and cognition in multiple sclerosis.

Lucas C Breedt, Giuseppe Pontillo, Fernando A N Santos, Chris Vriend, Ferran Prados, Alle Meije Wink, Alvino Bisecco, Alessandro Cagol, Massimiliano Calabrese, Marco Castellaro and 28 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Network neuroscience (Cambridge, Mass.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

38 authors.

Lucas C BreedtDepartment of Anatomy and Neurosciences, Amsterdam Neuroscience, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.ORCID https://orcid.org/0000-0001-8620-3017
Giuseppe PontilloMS Center Amsterdam, Amsterdam Neuroscience, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.
Fernando A N SantosDepartment of Anatomy and Neurosciences, Amsterdam Neuroscience, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.
Chris VriendDepartment of Anatomy and Neurosciences, Amsterdam Neuroscience, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.
Ferran PradosMS Center Amsterdam, Amsterdam Neuroscience, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.
Alle Meije WinkMS Center Amsterdam, Amsterdam Neuroscience, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.
Alvino BiseccoDepartment of Advanced Medical and Surgical Sciences, University of Campania "Luigi Vanvitelli," Naples, Italy.
Alessandro CagolTranslational Imaging in Neurology (ThINK) Basel, Department of Biomedical Engineering, Faculty of Medicine, University Hospital Basel and University of Basel, Basel, Switzerland.
Massimiliano CalabreseDepartment of Neurosciences, Biomedicine and Movement Sciences, University of Verona, Verona, Italy.
Marco CastellaroDepartment of Neurosciences, Biomedicine and Movement Sciences, University of Verona, Verona, Italy.
Sara ColloroneQueen Square Multiple Sclerosis Centre, Department of Neuroinflammation, UCL Queen Square Institute of Neurology, University College London, London, United Kingdom.
Rosa CorteseDepartment of Medicine, Surgery and Neuroscience, University of Siena, Siena, Italy.
Nicola De StefanoDepartment of Medicine, Surgery and Neuroscience, University of Siena, Siena, Italy.
Christian EnzingerDepartment of Neurology, Medical University of Graz, Graz, Austria.
Massimo FilippiNeuroimaging Research Unit, Division of Neuroscience, IRCCS San Raffaele Scientific Institute, Milan, Italy.
Michael A FosterQueen Square Multiple Sclerosis Centre, Department of Neuroinflammation, UCL Queen Square Institute of Neurology, University College London, London, United Kingdom.
Antonio GalloDepartment of Advanced Medical and Surgical Sciences, University of Campania "Luigi Vanvitelli," Naples, Italy.
Gabriel Gonzalez-EscamillaMovement Disorders, Neurostimulation and Neuroimaging, University Medicine Mainz, Mainz, Germany.
Cristina GranzieraTranslational Imaging in Neurology (ThINK) Basel, Department of Biomedical Engineering, Faculty of Medicine, University Hospital Basel and University of Basel, Basel, Switzerland.
Sergiu GroppaMovement Disorders, Neurostimulation and Neuroimaging, University Medicine Mainz, Mainz, Germany.
Einar A HøgestølDepartment of Neurology, Oslo University Hospital, Oslo, Norway.
Sara LlufriuNeuroimmunology and Multiple Sclerosis Unit and Laboratory of Advanced Imaging in Neuroimmunological Diseases (ImaginEM), Hospital Clinic and Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), University of Barcelona, Barcelona, Spain.
Eloy Martinez-HerasNeuroimmunology and Multiple Sclerosis Unit and Laboratory of Advanced Imaging in Neuroimmunological Diseases (ImaginEM), Hospital Clinic and Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), University of Barcelona, Barcelona, Spain.
Elisabeth SolanaNeuroimmunology and Multiple Sclerosis Unit and Laboratory of Advanced Imaging in Neuroimmunological Diseases (ImaginEM), Hospital Clinic and Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), University of Barcelona, Barcelona, Spain.
Silvia MessinaNuffield Department of Clinical Neurosciences, University of Oxford, Oxford, United Kingdom.
Marcello MocciaQueen Square Multiple Sclerosis Centre, Department of Neuroinflammation, UCL Queen Square Institute of Neurology, University College London, London, United Kingdom.
Gro O NygaardDepartment of Neurology, Oslo University Hospital, Oslo, Norway.
Jacqueline PalaceNuffield Department of Clinical Neurosciences, University of Oxford, Oxford, United Kingdom.
Daniela PinterDepartment of Neurology, Medical University of Graz, Graz, Austria.
Mara A RoccaNeuroimaging Research Unit, Division of Neuroscience, IRCCS San Raffaele Scientific Institute, Milan, Italy.
Ahmed ToosyQueen Square Multiple Sclerosis Centre, Department of Neuroinflammation, UCL Queen Square Institute of Neurology, University College London, London, United Kingdom.
Paola ValsasinaNeuroimaging Research Unit, Division of Neuroscience, IRCCS San Raffaele Scientific Institute, Milan, Italy.
Olga CiccarelliQueen Square Multiple Sclerosis Centre, Department of Neuroinflammation, UCL Queen Square Institute of Neurology, University College London, London, United Kingdom.
Eva M StrijbisMS Center Amsterdam, Amsterdam Neuroscience, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.
Frederik BarkhofMS Center Amsterdam, Amsterdam Neuroscience, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.
Menno M SchoonheimDepartment of Anatomy and Neurosciences, Amsterdam Neuroscience, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.
Linda DouwDepartment of Anatomy and Neurosciences, Amsterdam Neuroscience, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.
MAGNIMS study group

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

People with multiple sclerosis (MS) often present with cognitive deficits that cannot fully be attributed to focal brain alterations. Whole-brain network changes show stronger relations, but MS network insights have mostly focused on either structural or functional (single-layer) networks, while recent work has shown the importance of multilayer frontoparietal network integration for cognition. Here, we explored the cognitive relevance of multilayer integration of the frontoparietal network in relapsing-remitting MS (

Indexed as

Executive functioningFunctional connectivityGraph theoryMultilayer networksStructural connectivity

Identifiers

PMID42039096
PMCPMC13108497

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.