ReviewGalen medical journal2025
Scoliosis as a Paradigm of Pathological Spinal Curvature: Molecular Mechanisms and Imaging Innovations : Molecular and Imaging Insights in Scoliosis.
Review in Galen medical journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Pathological spinal curvature encompasses a broad spectrum of deformities that arise from a complex interplay of genetic, molecular, and biomechanical factors. This review synthesizes current knowledge on the molecular underpinnings of spinal deformities, with a focus on the dysregulation of non-coding RNAs, aberrant activation of the Wnt signaling pathway, inflammatory cytokine imbalances, and epigenetic modifications. In parallel, the article provides a detailed overview of both conventional and emerging imaging techniques used in the clinical assessment of spinal curvature. Traditional radiographic methods, such as Cobb angle measurement and Ferguson's method, are critically compared with advanced modalities-including surface topography, ultrasound imaging, and computer-aided 3D reconstructions-that promise enhanced diagnostic accuracy while minimizing radiation exposure. By bridging molecular insights with clinical imaging advancements, this review underscores the importance of an integrated diagnostic approach for early detection and effective management of scoliosis and related spinal deformities. The convergence of these disciplines not only enriches our understanding of the pathogenesis of spinal curvature but also lays the foundation for the development of personalized therapeutic strategies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.