ArticleGalen medical journal2025
Evaluating Ma-ol-asal Syrup for Chemotherapy-induced Fatigue in Gastrointestinal Cancer Patients: A Randomized Double-blinded Placebo-controlled Clinical Trial :.
Article in Galen medical journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Authors and funding
7 authors.
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Abstract
Background: Chemotherapy-induced fatigue (CIF) is a common and debilitating side effect in cancer patients, particularly those with gastrointestinal cancers. This study explores the potential of Ma-ol-asal, a traditional Persian herbal syrup, as a holistic, supportive approach to alleviate CIF's physical and psychological burdens. Materials and Methods: This randomized, double-blind, placebo-controlled trial involved 120 gastrointestinal cancer patients with fatigue, randomly assigned to receive 10 mL of Ma-ol-asal (compound honey syrup) or placebo thrice daily for four weeks. Fatigue was assessed with validated scales at baseline and post-intervention once, with data analyzed to evaluate efficacy. Results: After withdrawals, 42 patients per group remained. No significant demographic or lab differences were observed. Both groups had comparable scores post-treatment across all measures, with no significant differences. Adverse events, mainly nausea, vomiting, and abdominal pain, were similar. Perception of benefit varied between groups. Conclusion: Our study shows Ma-ol-asal syrup isn't superior to placebo for chemotherapy-induced fatigue, highlighting significant placebo effects. This emphasizes the need to understand harnessing placebo responses to improve symptom management safely.
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