ArticleGalen medical journal2025
Vaginal Progesterone Effects on Ultrasound Indices, Fetal Outcomes, and Preeclampsia in High-risk Pregnancy : Vaginal Progesterone in High-risk Pregnancy: Ultrasound Indices and Outcomes.
Article in Galen medical journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- Infant Viability in Severe Preeclampsia: Management Strategies and the Potential Role of Calprotectin-A Narrative Review.Children (Basel, Switzerland) · 2025Review
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: According to the high prevalence and importance of preeclampsia and its relationship with uterine artery resistance, the purpose of this study was to determine the effect of vaginal progesterone administration on ultrasound indices, fetal outcomes, and high-risk women pregnancy in terms of the incidence of preeclampsia. Materials and Methods: In this randomized, double-blind clinical trial, the number of 60 pregnant women between 11 to 14 weeks with risk factors for preeclampsia were examined according to the inclusion criteria and based on random assignation method in two groups of 30 patients (intervention group: 80 mg aspirin tablets + 400 mg vaginal progesterone suppositories and control group: 80 mg aspirin tablets) based on maternal and fetal outcomes and uterine artery color Doppler ultrasound (pulsatility index (PI) and vascular resistance index (RI). Results: The prevalence of preterm birth in the intervention group was lower significantly difference (P≤0.05). In the intervention group, uterine artery PI after the study had a greater decrease than before the study on the right side (0.33±0.42 vs. 0.05±0.28, P≤0.05) and on the left side (0.38±0.49 vs. 0.09±0.2, P≤0.05), compared to the control group. In the intervention group, uterine artery RI after the study had a greater decrease than before the study on the right side (0.20±0.31 vs. 0.02±0.10, P≤0.05) and on the left side (0.22±0.3 vs. 0.03 ± 0.1, P≤0.05), compared to the control group. Conclusion: Progesterone suppositories in addition to aspirin, can reduce the prevalence of preterm birth and uterine artery PI and RI values.
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