ArticleJournal of reproduction & infertility2025
Neuroendocrine Tumors Identified During Laparoscopic Endometriosis Surgery: A Report of 6 Cases.
Article in Journal of reproduction & infertility, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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5 authors.
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Abstract
Background: Neuroendocrine tumors (NETs) or carcinoid tumors are rare neoplasms originating from neuroendocrine cells, most commonly found in the appendix. While NETs are often asymptomatic, they may present with abdominal pain, flushing, and diarrhea and are frequently discovered incidentally during surgery for other conditions. Endometriosis has been associated with an increased risk of certain malignancies; however, its relationship with NETs remains unclear. Given the high frequency of laparoscopic surgeries for endometriosis, incidental NET findings pose unique clinical challenges. Methods: This retrospective case report was conducted at Avicenna Fertility Center, Affiliated to Avicenna Research Institute, Tehran, Iran, from 2016 to 2024. Medical records of six patients (33-55 years old) who underwent laparoscopic surgery for endometriosis, with incidental NETs found in the appendix, were analyzed. Clinical presentation, intraoperative findings, histopathology, and postoperative outcomes were reviewed. Results: Six women (mean age: 43.7 years) with endometriosis-related symptoms (dysmenorrhea, dyspareunia, and pelvic pain) underwent laparoscopic surgery with appendectomy. The NETs (2-9 Conclusion: Incidental NET detection during endometriosis surgery highlights the need for routine pathological examination of appendectomy specimens. While no direct link exists between NETs and endometriosis, recognizing these tumors may influence surgical decisions and postoperative management, emphasizing the importance of multidisciplinary care.
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