ArticleGMS hygiene and infection control2026
Suspected community-acquisition of carbapenem-resistant hypervirulent Klebsiella pneumoniae (CRhvKp) in Germany: a case report and implications for infection control.
Article in GMS hygiene and infection control, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Aim: Hypervirulent Methods: We established a two-step screening approach for the routine diagnostic detection of hvKp, combining loop-mediated isothermal amplification (LAMP) with confimatory whole-genome sequencing (WGS). This workflow was applied to all carbapenemase producing Results: We report the case of a 1973-born male patient with a history of Child-Pugh class B cirrhosis who was admitted due to acute liver failure and ascites triggered by infection. The patient had no recent travel history but had been recently admitted to local hospitals in Thuringia, Germany. Ascitic fluid obtained by paracentesis appeared putrid and yielded an ESBL-producing and fluoroquinolone-resistant Escherichia coli. In addition, a lower urinary tract infection due to CRhvKp was identified. The CRhvKp infection was deemed community-acquired, with the route of acquisition remaining unknown. The isolate belonged to ST147 and carried the Conclusion: CRhvKp can occur in patients without establishes epidemiological or clinical risk factors, suggesting a broader reservoir than currently assumed. Further research regarding prevalence, transmissibility, environmental persistence, and colonization dynamics of CRhvKp strains are urgently needed to determine their implications for infection prevention and control in hospitals in Germany.
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