Evidence map›Paper›PMID 42038665›Full record

ArticleHeart rhythm O22026

Single or multiple pulsed field applications: Intracardiac electrogram changes and implications for procedural end points.

Vincent Schlageter, Patrick Badertscher, David Spreen, Adrian Luca, Philipp Krisai, Behnam Subin, Nicolas Schaerli, David Zivanovic, Thomas Kueffer, Felix Mahfoud and 3 more

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Article in Heart rhythm O2, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Vincent SchlageterDepartment of Cardiology, University Hospital Basel, University of Basel, Basel, Switzerland.
Patrick BadertscherDepartment of Cardiology, University Hospital Basel, University of Basel, Basel, Switzerland.
David SpreenDepartment of Cardiology, University Hospital Basel, University of Basel, Basel, Switzerland.
Adrian LucaDepartment of Cardiology, Lausanne University Hospital, University of Lausanne, Lausanne, Switzerland.
Philipp KrisaiDepartment of Cardiology, University Hospital Basel, University of Basel, Basel, Switzerland.
Behnam SubinDepartment of Cardiology, University Hospital Basel, University of Basel, Basel, Switzerland.
Nicolas SchaerliDepartment of Cardiology, University Hospital Basel, University of Basel, Basel, Switzerland.
David ZivanovicDepartment of Cardiology, University Hospital Basel, University of Basel, Basel, Switzerland.
Thomas KuefferDepartment of Cardiology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
Felix MahfoudDepartment of Cardiology, University Hospital Basel, University of Basel, Basel, Switzerland.
Michael KühneDepartment of Cardiology, University Hospital Basel, University of Basel, Basel, Switzerland.
Christian SticherlingDepartment of Cardiology, University Hospital Basel, University of Basel, Basel, Switzerland.
Sven KnechtDepartment of Cardiology, University Hospital Basel, University of Basel, Basel, Switzerland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Pulsed field ablation (PFA) using a pentaspline catheter is increasingly applied for pulmonary vein (PV) isolation, but standardized methods to assess durable lesion formation are lacking. Objective: We aimed to investigate the impact of incremental PFA applications on electrogram (EGM) characteristics and determine whether EGM signatures serve as markers for effective lesions. Methods: PV EGMs of a cohort of consecutive patients were analyzed before and after single, double, and quadruple PFA applications. Bipolar voltage amplitude (BVA) and signal power in different frequency bands (>50 Hz, >75 Hz, and >125 Hz [HF125]) were quantified. EGMs were reassessed after 60 seconds, and pacing was performed to evaluate PV pace capture. Results: This analysis included 4230 EGMs of 83 patients. Immediately after ablation, no differences in BVA and frequency power were observed between groups. After 60 seconds, significant differences were present for all features in the single, double, and quadruple groups: BVA (0.27 mV vs 0.26 mV vs 0.13 mV), >50 Hz (39 μV Conclusion: Only quadruple PFA applications ensured persistent lesion effects over the observation period. A combined end point using an HF125 cutoff of 2.5 μV

Indexed as

Acute effectBipolar voltageElectrogramEnd point definitionFrequency analysisPulmonary vein isolationPulsed field ablation

Identifiers

PMID42038665
PMCPMC13107057

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.