ArticleAntimicrobial stewardship & healthcare epidemiology : ASHE2026
Safety of short versus extended antibiotic therapy for neutropenic fever after hematopoietic cell transplantation.
Article in Antimicrobial stewardship & healthcare epidemiology : ASHE, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: To determine safety and effectiveness of short (≤7 d) versus extended (>7 d) antibiotic courses for neutropenic fever in HCT recipients. Design: Retrospective cohort study. Setting: Private tertiary referral center. Participants: Consecutive sample; all patients >18 years old admitted between January 2019 and May 2024 with neutropenic fever during their index hospitalization for HCT. Methods: Data were collected via chart review. Primary outcomes were clinical failure (30-day mortality or ICU admission) and adverse events ( Results: Among 103 patients (55 short, 48 extended), mean antibiotic duration was 3.6 days (short) and 11.9 days (extended). There were more leukemia and allogeneic HCT recipients in the extended group. In multivariable analyses, antibiotic duration was not predictive of clinical failure (odds ratio [OR] 3.40; 95% confidence interval [CI], 0.50-27.55; Conclusions: We found that shorter antibiotic courses were not associated with worse clinical outcomes or adverse events in HCT patients with neutropenic fever in the early posttransplant period. These findings support emerging evidence favoring shorter therapy.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.