ArticleAntimicrobial stewardship & healthcare epidemiology : ASHE2026
Implementation of the early-onset sepsis calculator in a tertiary care NICU.
Article in Antimicrobial stewardship & healthcare epidemiology : ASHE, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Erratum: Implementation of the Early-Onset Sepsis Calculator in a Tertiary Care NICU - CORRIGENDUM.Antimicrobial stewardship & healthcare epidemiology : ASHE · 2026Article
Corrections and comments
- Erratum issued
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: Early-onset sepsis (EOS) is a significant cause of neonatal morbidity and mortality. Due to fear of missing cases, many newborns are unnecessarily exposed to antibiotics. We implemented the neonatal EOS calculator to reduce over-utilization of antibiotics and decrease costs. Design: Quality improvement study. Setting: Neonatal Intensive Care Unit (NICU). Patients: Infants born at ≥34 weeks' gestation were divided between two periods: the pre-EOS calculator time frame and the post-EOS calculator time frame. Intervention: We changed our EOS evaluation for inborn infants by implementing the EOS-calculator and decreasing "rule-out sepsis" time frame from 48 to 36 hours for infants started on antibiotics. Results: 1,306 infants, with similar demographics, were included: 814 in pre-EOS calculator time frame and 492 in post-EOS calculator time frame. Following our interventions, the percentage of NICU admissions ≥34 weeks' gestation started on antibiotics decreased from 62% to 51% ( Conclusions: Antibiotic usage significantly decreased, with substantial savings after implementation of the EOS calculator, without significant negative effects.
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Registered trials
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