ArticleAntimicrobial stewardship & healthcare epidemiology : ASHE2026
A tool based on objective data to identify patients at elevated risk of hospital-onset
Article in Antimicrobial stewardship & healthcare epidemiology : ASHE, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objective: Identify patients at increased risk of hospital-onset Design: Nested case-control study. Setting: A large, inner city, tertiary care center between January 1, 2011 and August 31, 2020. Participants: 375 cases and 2,248 matched controls. Methods: All hospitalized persons ≥18 years, found to have SA bacteremia at least 48 hours after admission were matched to 1-12 controls on birth year, race/ethnicity, sex, and month and year of admission. Vital signs and lab results were coded as "low" or "high" based on laboratory definitions. Multivariable models identified patient characteristics associated with an increased risk of SA bacteremia. Results: SA bacteremia was associated with high aspartate aminotransferase (AST) (>35 u/L )(HR = 1.92, 95%CI (1.30, 2.83), Conclusions: A prediction tool applied on admission of hospital stay ≥15 days OR any elevated two of the following: AST, creatinine, CO2, or total protein has sensitivity between 57%-64% and specificity to between 65%-78%.
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