ArticleAntimicrobial stewardship & healthcare epidemiology : ASHE2026
Longitudinal analysis of antimicrobial consumption and economic outcomes of surgical prophylaxis stewardship in a wartime Ukrainian maternity hospital.
Article in Antimicrobial stewardship & healthcare epidemiology : ASHE, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objective: To analyze the dynamics of antimicrobial consumption and evaluate the clinical and economic outcomes of a comprehensive antimicrobial stewardship (AMS) program in a Ukrainian maternity hospital. Design: Retrospective observational study. Methods: The study was conducted at a tertiary referral maternity hospital in Kyiv, Ukraine, using two datasets. First, a longitudinal analysis of pharmacy dispensing records (2020-2024) was performed to assess consumption trends. Second, a comparative cohort analysis of 320 women undergoing gynecological surgery (preAMS [2018] vs postAMS [2023]; Results: A profound structural shift occurred: consumption of ceftriaxone decreased from 72.4% of total prophylactic units in 2020 to 1.4% in 2024, replaced by cefazolin (0% to 44.0%). In the clinical cohorts, unjustified postoperative antibiotic use was eliminated (46.3% in 2018 to 0% in 2023; Conclusions: Institution-level stewardship interventions successfully shifted prescribing toward guideline-concordant use and generated substantial cost savings. This study demonstrates the resilience and feasibility of low-cost stewardship models in high-pressure, transitional healthcare environments.
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