Evidence map›Paper›PMID 42038520›Full record

ArticleBioinformatics advances2026

Leveraging training expertise to build capacity in computational personalised medicine.

Marta Lloret-Llinares, Daniel Thomas-Lopez, José Carbonell-Caballero, Laurence Calzone, Javier Conejero, Jesse P Harrison, Miroslav Kratochvil, Arnau Montagud, Vincent Noël, Henrik Nortamo and 13 more

Abstract read
In one paragraph

Article in Bioinformatics advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors.

Marta Lloret-LlinaresEMBL's European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, Cambridge, CB10 1SD, United Kingdom.ORCID https://orcid.org/0000-0002-8205-9799
Daniel Thomas-LopezEMBL's European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, Cambridge, CB10 1SD, United Kingdom.
José Carbonell-CaballeroBarcelona Supercomputing Center (BSC), Barcelona, 08034, Spain.
Laurence CalzoneInstitut Curie, Université PSL, Paris, F-75005, France.ORCID https://orcid.org/0000-0002-7835-1148
Javier ConejeroBarcelona Supercomputing Center (BSC), Barcelona, 08034, Spain.
Jesse P HarrisonCSC-IT Center for Science Ltd, Espoo, FI-02101, Finland.
Miroslav KratochvilLuxembourg Centre for Systems Biomedicine, University of Luxembourg, Belvaux, L-4367, Luxembourg.ORCID https://orcid.org/0000-0001-7356-4075
Arnau MontagudBarcelona Supercomputing Center (BSC), Barcelona, 08034, Spain.ORCID https://orcid.org/0000-0002-7696-1241
Vincent NoëlInstitut Curie, Université PSL, Paris, F-75005, France.ORCID https://orcid.org/0000-0003-3448-291X
Henrik NortamoCSC-IT Center for Science Ltd, Espoo, FI-02101, Finland.
Miguel Ponce-de-LeónBarcelona Supercomputing Center (BSC), Barcelona, 08034, Spain.ORCID https://orcid.org/0000-0002-7496-844X
Pablo Rodríguez-MierHeidelberg University, Faculty of Medicine, and Heidelberg University Hospital, Institute for Computational Biomedicine, Heidelberg, 69120, Germany.ORCID https://orcid.org/0000-0002-4938-4418
Marco RusconeBarcelona Supercomputing Center (BSC), Barcelona, 08034, Spain.
Dénes TüreiHeidelberg University, Faculty of Medicine, and Heidelberg University Hospital, Institute for Computational Biomedicine, Heidelberg, 69120, Germany.
Miguel VazquezBarcelona Supercomputing Center (BSC), Barcelona, 08034, Spain.
Alessandra VillaKTH, Royal Institute of Technology, SE-100 44, Stockholm, Sweden.
Nadja ZlenderUniversity of Ljubljana, Ljubljana, SI-1104, Slovenia.
Brane LeskosekUniversity of Ljubljana, Ljubljana, SI-1104, Slovenia.
Mariano VazquezBarcelona Supercomputing Center (BSC), Barcelona, 08034, Spain.
PermedCoE consortium
Alfonso ValenciaBarcelona Supercomputing Center (BSC), Barcelona, 08034, Spain.
Vera MatserEMBL's European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, Cambridge, CB10 1SD, United Kingdom.
Cath BrooksbankEMBL's European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, Cambridge, CB10 1SD, United Kingdom.ORCID https://orcid.org/0000-0001-9395-7001

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Summary: Rapid development of genomic technologies in recent years enables personalised medicine to become an essential part of healthcare. Advanced computational methods are required to extract relevant insights that can be applied in clinical settings. This presents a challenge for clinicians and biomedical researchers, who need specialised training to adopt these tools. Within the context of PerMedCoE, the first European Centre of Excellence in Personalised Medicine, we developed and delivered a competency-based training programme to support professionals in the life sciences to work with modelling and simulation tools that integrate omics data to identify biological processes relevant to disease. We identified a set of required competencies in the field and built a series of career profiles with specific competence levels in these. The competencies and profiles contributed to define the focus and target audience of the training activities delivered: a combination of self-paced learning resources, webinars and online and face-to-face synchronous courses. The outputs of the programme (competencies, career profiles and training materials) can be used by biomedical professionals for their own career development or to train others. In addition, the approach can be adopted by other fields with rapid technological advancements and a constant need to upskill professionals. Availability and implementation: The competency framework is reproduced in full in this paper as supplementary material and available on the Competency Hub at https://competency.ebi.ac.uk/framework/permedcoe/2.1.

Identifiers

PMID42038520
PMCPMC13110006

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.