ArticleSmart molecules : open access2026
Targeting cancer cell mitochondria with a multivalent source of singlet oxygen.
Article in Smart molecules : open access, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- Smart mesoporous silica nanoparticles for precision cancer therapy: Tumor targeting and stimuli-responsive controlled release.Smart molecules : open access · 2026Review
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5 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Naphthalene, anthracene and pyridone endoperoxides are known to thermally release singlet oxygen. However, in the cycloreversion reaction, singlet oxygen is produced stoichiometrically; therefore, multiple singlet oxygen releasing modules are expected to be very useful in inducing apoptosis of cancer cells. Herein, we present a potential therapeutic agent presenting three-pyridone endoperoxide modules and a mitochondria targeting group. Compared to previously reported pyridone-based monofunctional endoperoxides, the triple endoperoxide is highly effective as evidenced by assays and fluorescence microscopy.
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