ArticleFrontiers in bioinformatics2026
Bulk RNA-seq datasets analysis integration identifies robust drought-responsive genes and functional networks in
Article in Frontiers in bioinformatics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Introduction: Methods: We conducted a meta-analysis of three independent RNA-Seq drought studies in Results: We identified a high-confidence set of 472 differentially expressed genes (DEGs), including 274 upregulated and 198 downregulated genes. Functional analysis revealed a growth-defense tradeoff, with upregulated genes associated with stress response pathways such as protein folding, osmolyte biosynthesis, and ABA signaling, while genes involved in cell division, DNA replication, and cell wall biosynthesis were repressed. Protein-protein interaction analysis showed a coordinated network linking stress response activation to suppression of growth-related processes. Discussion: These findings provide a robust catalog of candidate genes, including previously uncharacterized proteins, supporting future functional studies and molecular breeding strategies aimed at enhancing drought tolerance in eucalyptus under climate change.
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