ArticleFrontiers in bioinformatics2026
Integrated molecular dynamics elucidation of TP53 H179 zinc-binding variants: genomic and structural characterization across NSCLC subtypes.
Article in Frontiers in bioinformatics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Computational insights into synergistic mechanisms of PD-901 and 5-azacitidine targeting PTPN11 (SHP2) E76K mutation in juvenile myelomonocytic leukemia.Frontiers in bioinformatics · 2026Article
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Abstract
Background: Non-Small Cell Lung Cancer (NSCLC), the most prevalent form of pulmonary malignancy, is primarily classified into lung adenocarcinoma (LUAD) and lung squamous cell carcinoma (LUSC). Methods: TCGA mutational profiles were evaluated for 616 LUAD and 544 LUSC individuals. This study focuses on mutational perturbations at the His179 locus, a key residue within the protein's zinc-binding motif. Frequent substitutions at H179 (Y/R/N/L/D) were identified across LUAD and LUSC cohorts. The structural and functional ramifications of these mutations were studied using combinatorial static structural analysis and atomistic molecular dynamics simulations (MDS). Conformational trajectories were analyzed to assess alterations in protein flexibility and functionally critical regions. Binding affinity values of the protein with Zn Results: C > A was the predominant single-nucleotide substitution observed, with Discussion: The results observed underscore the pathogenic potential of His179 mutations within the p53 Zinc-binding motif. The findings highlight the critical role of the Zinc-binding motif in maintaining p53's conformational fidelity and suggest that specific substitutions may differentially modulate its tumor-suppressive function.
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