ArticleFrontiers in oncology2026
Spatial transcriptional mapping reveals the molecular characteristics of juxtaglomerular cell tumors.
Article in Frontiers in oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Aside from renin expression, little is known about the molecular markers or signaling pathways involved in the pathogenesis of Juxtaglomerular Cell Tumors (JGCTs). This study aimed to elucidate the molecular characteristics underlying JGCTs. Methods: An 8-year-old girl diagnosed with JGCT underwent laparoscopic partial nephrectomy. Paraffin-embedded tumor tissues were obtained for Spatial Transcriptomic sequencing (STs). The publicly available TCGA database was used to compare the gene expression profiles with those from STs. Results: The patient presented with typical clinical manifestations of JGCTs. Spatial transcriptomic analysis revealed that juxtaglomerular cells were surrounded by dendritic, endothelial, mast cells, and luminal cells. High expression of Conclusion: Spatial transcriptomics revealed that high KISS1 expression plays a key role in JGCT development. In addition, the PPARG, NOTCH, and PDGFB pathways were identified as potential regulators of renin secretion.
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