Evidence map›Paper›PMID 42038336›Full record

ArticleFrontiers in cellular neuroscience2026

Intestinal inflammation promotes neuroinflammation and PD-associated nigrostriatal pathology independently of LRRK2 G2019S kinase activity.

Andrea R Merchak, Mary K Herrick, Madelyn C Houser, Cody E Keating, Jianjun Chang, Malú Gámez Tansey

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in cellular neuroscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Andrea R Merchak *Department of Neuroscience, University of Florida College of Medicine, Gainesville, FL, United States.
Mary K Herrick *Department of Physiology, Emory University School of Medicine, Atlanta, GA, United States.
Madelyn C HouserDepartment of Physiology, Emory University School of Medicine, Atlanta, GA, United States.
Cody E KeatingDepartment of Physiology, Emory University School of Medicine, Atlanta, GA, United States.
Jianjun ChangDepartment of Physiology, Emory University School of Medicine, Atlanta, GA, United States.
Malú Gámez TanseyDepartment of Neuroscience, University of Florida College of Medicine, Gainesville, FL, United States.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: The pathogenesis of Parkinson's disease (PD) has been linked to environmental factors, toxins, genetics, and peripheral inflammation. Importantly, intestinal inflammation like that seen in Crohn's disease (CD) or food allergies has been implicated in risk for neurodegeneration and late-onset PD. Further, CD and PD share genetic risk factors including gain-of-function leucine-rich repeat kinase 2 ( Methods: We utilized bacterial artificial chromosome (BAC) mice overexpressing wildtype mouse Results: While our data revealed regulation of the brain inflammatory state by Discussion: While

Indexed as

circulating cytokinesdopaminergic (DA) neuronG2019S BAC overexpressionintestinal inflammationneuroinflammation

Identifiers

PMID42038336
PMCPMC13105876

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.