Evidence map›Paper›PMID 42038280›Full record

ArticleJournal of the Endocrine Society2026

Weight loss lifestyle intervention and bone health hormonal markers in type 2 diabetes: analysis from look AHEAD study.

Jiahuan Helen He, Chigolum P Oyeka, Jianqiao Ma, Nityasree Srialluri, Teresa Gisinger, Mark Woodward, Erin D Michos, Karen C Johnson, Kendall F Moseley, Wendy L Bennett and 1 more

Abstract read
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Article in Journal of the Endocrine Society, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Jiahuan Helen HeDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA.ORCID https://orcid.org/0009-0006-7769-4444
Chigolum P OyekaDivision of General Internal Medicine, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Jianqiao MaDepartment of Epidemiology, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX 77030, USA.
Nityasree SrialluriDivision of Nephrology, Department of Medicine, Johns Hopkins University, Baltimore, MD 21205, USA.
Teresa GisingerDivision of Endocrinology and Metabolism, Department of Internal Medicine III, Medical University of Vienna, Vienna 1090, Austria.
Mark WoodwardThe George Institute for Global Health, School of Public Health, Imperial College London, London W12 7RZ, UK.ORCID https://orcid.org/0000-0001-9800-5296
Erin D MichosDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA.ORCID https://orcid.org/0000-0002-5547-5084
Karen C JohnsonDepartment of Preventive Medicine, University of Tennessee Health Science Center, Memphis, TN 38163, USA.
Kendall F MoseleyDivision of Endocrinology, Diabetes and Metabolism, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.ORCID https://orcid.org/0000-0003-2500-2312
Wendy L BennettDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA.
Dhananjay VaidyaDivision of General Internal Medicine, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.ORCID https://orcid.org/0000-0002-7164-1601

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Context: Intensive lifestyle interventions (ILI) in people with type 2 diabetes (T2D) not only promote weight loss but are also associated with bone loss and increased fracture risk. The hormonal mechanisms regulating calcium metabolism that may underlie these changes remain to be investigated. Objective: To evaluate the association between a weight loss-targeted ILI on 25-hydroxyvitamin D [25(OH)D], parathyroid hormone (PTH), and vitamin D-binding protein (VDBP) in adults with T2D. Methods: We derived data from a randomly selected subset of participants (n = 123) from Look AHEAD (Action for Health in Diabetes), a randomized controlled trial comparing ILI (caloric restriction and physical activity) with diabetes support and education (DSE) in adults with overweight/obesity and T2D. Covariate-adjusted linear mixed regressions were used to examine the effect of ILI on changes in 25(OH)D, PTH, and VDBP at year 1 (weight-loss nadir) and year 4. Results: At year 1, 25(OH)D had an ILI-related increase of 2.04 ng/mL (95% CI: 0.20, 3.88) and PTH had an ILI-related suppression of -6.75 pg/mL (95% CI: -11.4, 2.13). By year 4, these effects were no longer observed as DSE had a delayed increase in 25(OH)D and PTH returned to baseline levels in both groups. No significant treatment effect was observed for VDBP. Conclusion: Intensive lifestyle intervention was associated with an increase in 25(OH)D and suppression of PTH elevation during the period of maximal weight loss. These findings suggest that weight loss-targeted lifestyle interventions may influence hormones regulating calcium metabolism, highlighting the need to examine whether such hormonal alterations contribute to bone mineralization during weight loss.

Indexed as

bone mineral densitiescalcium metabolismdiabeteslifestyle interventionparathyroid hormonesvitamin D

Identifiers

PMID42038280
PMCPMC13107178

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.