ArticleClinical interventions in aging2026
Identification of a High Visceral Adiposity Phenotype: A Cluster Analysis-Based Stratification of NAFLD Risk in the Elderly.
Article in Clinical interventions in aging, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Non-alcoholic fatty liver disease (NAFLD), the most prevalent chronic liver disease globally, is closely linked to obesity and metabolic dysregulation. However, the relative contributions of overall adiposity versus body fat distribution patterns to NAFLD pathogenesis, particularly in the elderly population, remain incompletely understood. Objective: This study aimed to investigate the association between cluster-derived body composition phenotypes and NAFLD risk, and identify independent risk factors for NAFLD. Methods: This cross-sectional study enrolled 239 elderly participants. Body composition parameters (whole-body and regional fat percentages, visceral adipose tissue (VAT) area, fat-free mass) were measured via dual-energy X-ray absorptiometry (DXA). Participants were divided into NAFLD and non-NAFLD groups by abdominal ultrasonography. Inter-group comparisons were performed with Student's t-tests and chi-square tests. Cluster analysis was applied to identify distinct body composition phenotypes. Univariate and multivariate logistic regression were used to screen independent NAFLD risk factors, and ROC curve analysis evaluated the model's predictive performance. Results: The NAFLD group showed more prominent central obesity ( Conclusion: In the elderly, visceral fat accumulation and central fat distribution, rather than overall adiposity itself, are key body composition features linked to NAFLD. The high visceral fat central obesity phenotype correlates with the highest metabolic risk and NAFLD prevalence, and the trunk-to-leg fat ratio is a robust NAFLD predictor.
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